Cell Interactions in Neuroblastoma

  • A. J. Harris
  • W. G. Hopkins


Orderly and specific patterns of interconnections among nerve cells appear to be of primary significance in determining nervous system function. Accordingly, the question of how such interconnections develop and become stabilized is prominent in much present-day neurobiological research. This question has many experimentally separable aspects: for example, a developing neuron must extend neurites which make contact with other cells; these contacts must mature functionally until they can communicate, chemically or electrically; the contacts must be validated as being appropriate to the developmental plan of the organism; appropriate contacts must be stabilized; the cells making them may be inhibited from forming further connections with other cells; and inappropriate contacts should be made nonfunctional by deletion, by pre- or postsynaptic cell death, or by losing their ability to transmit.


Botulinum Toxin Neuroblastoma Cell Muscle Membrane Coated Vesicle Clonal Cell Line 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. J. Harris
    • 1
  • W. G. Hopkins
    • 1
  1. 1.Department of PhysiologyUniversity of Otago Medical SchoolDunedinNew Zealand

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