Junctional Permeability and Its Consequences

  • John D. Pitts
  • Malcolm E. Finbow


For the last 100 years attention has been focused on the cell as the unit of life, and indeed this important concept has formed the basis for much of our understanding of structure and function in biological systems. Although this concept is meaningful and accurate for prokaryotes and other unicellular organisms, the cell in a highly developed multicellular organism must lose much of its independence in the milieu of the composite tissues. We must now accept that multicellular organisms are populations of interacting and interdependent cells with properties which cannot be assigned specifically to individual units but instead must be collectively assigned to all the different cells which together are the developing embryo or the adult tissue.


Mutant Cell Donor Cell Recipient Cell Intercellular Junction Purine Nucleotide 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • John D. Pitts
    • 1
  • Malcolm E. Finbow
    • 1
  1. 1.Department of BiochemistryUniversity of GlasgowGlasgowScotland

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