Measurement of Myocardial Blood Flow Using 133Xe

  • Robert W. Parkey
  • Frederick J. Bonte
  • Ernest M. Stokely
  • George C. Curry
  • James T. Willerson
Part of the Topics in Cardiovascular Disease book series (TCAD)


In 1945, Kety and Schmidt1 devised a method to measure cerebral blood flow using a diffusible indicator, nitrous oxide. In 1949, Kety2 substituted 24Na and described the first practical method to measure blood flow using a radionuclide tracer. In the following years, some groups3–11 elaborated further on Kety’s work and developed methods for measuring myocardial blood flow by injection of diffusible tracers into a coronary artery or into the myocardium itself. The disappearance, or “washout,” of radioactivity was measured by an external radiation-detection system placed over the myocardium. Kety had shown that the rate of washout of the diffusible indicator from tissue to blood was a function of tissue blood flow.1,2,12


Myocardial Blood Flow Regional Myocardial Blood Flow Experimental Myocardial Infarction Transmural Infarction Regional Myocardial Perfusion 
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Robert W. Parkey
    • 1
  • Frederick J. Bonte
    • 1
  • Ernest M. Stokely
    • 1
  • George C. Curry
    • 1
  • James T. Willerson
    • 1
  1. 1.Department of Medicine Southwestern Medical SchoolThe University of Texas Health Science CenterDallasUSA

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