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Measurement of Myocardial Blood Flow Using 133Xe

  • Robert W. Parkey
  • Frederick J. Bonte
  • Ernest M. Stokely
  • George C. Curry
  • James T. Willerson
Part of the Topics in Cardiovascular Disease book series (TCAD)

Abstract

In 1945, Kety and Schmidt1 devised a method to measure cerebral blood flow using a diffusible indicator, nitrous oxide. In 1949, Kety2 substituted 24Na and described the first practical method to measure blood flow using a radionuclide tracer. In the following years, some groups3–11 elaborated further on Kety’s work and developed methods for measuring myocardial blood flow by injection of diffusible tracers into a coronary artery or into the myocardium itself. The disappearance, or “washout,” of radioactivity was measured by an external radiation-detection system placed over the myocardium. Kety had shown that the rate of washout of the diffusible indicator from tissue to blood was a function of tissue blood flow.1,2,12

Keywords

Myocardial Blood Flow Regional Myocardial Blood Flow Experimental Myocardial Infarction Transmural Infarction Regional Myocardial Perfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kety, S. S., and Schmidt, C. F., The determination of cerebral blood flow in man by use of nitrous oxide in low concentrations, Amer. J. Physiol. 143: 53 (1945).Google Scholar
  2. 2.
    Kety, S. S., Measurement of regional circulation by the local clearance of radioactive sodium, Amer. Heart J. 38: 321 (1949).PubMedCrossRefGoogle Scholar
  3. 3.
    Cullen, M. L., and Reese, H. L., Myocardial circulatory changes measured by the clearance of NA24-effect of common duct distension of myocardial circulation, J. Appl. Physiol. 5: 281 (1952).PubMedGoogle Scholar
  4. 4.
    Rees, J. R., Redding, V. J., Ashfield, R., Gibson, D., and Gavey, C. J., Myocardial blood flow measurement with 133xenon-effect of glyceryl trinitrate in dogs, Brit. Heart J. 28: 374–381 (1966).PubMedCrossRefGoogle Scholar
  5. 5.
    Herd, J. A., Hollenberg, M., Thornburn, G. D., Kopald, H. H., and Barger, A. C., Myocardial blood flow determined with krypton-85 in unanesthetized dogs, Amer. J. Physiol. 203:122 (1962).Google Scholar
  6. 6.
    Ross, R. S., Ueda, K., Lichtlen, P. R., and Rees, J. R., Measurement of myocardial blood flow in animals and man by selective injection of radioactive inert gas into the coronary arteries, Circ. Res. 15: 28 (1964).PubMedCrossRefGoogle Scholar
  7. 7.
    Cohen, L. S., Elliott, W. C., and Gorlin, R., Measurement of myocardial blood flow using krypton-85, Amer. J. Physiol. 206: 997 (1964).PubMedGoogle Scholar
  8. 8.
    Wagner, H. N., Jr., Regional blood flow measurments with krypton-85 and xenon-133, in: Dynamic Clinical Studies with Radioisotope ( R. M. Knisely and W. W. Tauze, Eds.), Atomic Energy Commission, Oak Ridge (1964).Google Scholar
  9. 9.
    Sullivan, J. M., Taylor, W. J., Elliott, W. C., and Gorlin, R., Regional myocardial blood flow, J. Clin. Invest. 46:1402 (1967).PubMedCrossRefGoogle Scholar
  10. 10.
    Brandi, G., Fam, W. M., and McGregor, M., Measurement of coronary flow in local areas of myocardium using xenon-133, J. Appl. Physiol. 24: 446 (1968).PubMedGoogle Scholar
  11. 11.
    Rees, J. R., and Redding, V. J., Experimental myocardial infarction in the dog; comparison of myocardial blood flow within, near and distant from the infarct, Circ. res. 25: 161 (1969).PubMedCrossRefGoogle Scholar
  12. 12.
    Eckenhoff, J. E., Hafkenschiel, J. H., Harmel, M. H., Goodale, W. T., Lubin, M., Bing, R. J., and Kety, S. S., Measurement of coronary blood by the nitrous oxide method, Amer. J. Physiol. 152: 356 (1948).PubMedGoogle Scholar
  13. 13.
    Conn, H. L., Jr., Equilibrium distribution of radioxenon in tissue: xenon-hemoglobin association curve, J. Appl. Physiol. 16: 1065 (1961).PubMedGoogle Scholar
  14. 14.
    Holmberg, S., Luepker, R., and Varnauskas, E., Influence of recirculation on myocardial clearance curves with xenon-133, Acta Med. Scand. 189: 241 (1971).PubMedCrossRefGoogle Scholar
  15. 15.
    Hoedt-Rasmussen, K., Sveinsdottir, E., and Lassen, N. E., Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas, Circ. Res. 18: 237 (1966).PubMedCrossRefGoogle Scholar
  16. 16.
    Johansson, B., Linder, E., Seeman, T., Collateral blood flow in the myocardium of dogs measured with krypton-85, Acta Physiol. Scand. 62: 263 (1964).PubMedCrossRefGoogle Scholar
  17. 17.
    Horwitz, L. D., Gorlin, R., Taylor, W. J., and Kemp, H. G., Effects of nitroglycerin on regional myocardial blood flow in coronary artery disease, J. Clin. Invest. 50: 1578 (1971).PubMedCrossRefGoogle Scholar
  18. 18.
    Parkey, R. W., Lewis, S. E., Stokely, E. M., and Bonte, F. J., Compartmental analysis of the 133Xe regional myocardial blood-flow curve, Radiology 104: 425 (1972).PubMedGoogle Scholar
  19. 19.
    Smith, S. C., Jr., Gorlin, R., Herman, M. V., Taylor, W. J., and Collins, J. J., Jr., Myocardial blood flow in man: Effects of coronary collateral circulation and coronary artery bypass surgery, J. Clin. Invest. 51: 2556 (1972).PubMedCrossRefGoogle Scholar
  20. 20.
    Holman, B. L., Adams, D. F., Jewitt, D., Per Eld, H., Iodine, J., Cohn, P. F., Gorlin, R., and Adelstein, S. J., Measuring regional myocardial blood flow with 133Xe and the Anger camera, Radiology 112:99 (1974).Google Scholar
  21. 21.
    Hills, B. A., An assessment of the expression of C = Q (1-exp (-PSIQ) for estimating capillary permeabilities, Phys. Med. Biol. 15: 705 (1970).PubMedCrossRefGoogle Scholar
  22. 22.
    Gosselin, R. E., and Stibitz, G. R., Rates of solute absorption from tissue depots: theoretical considerations, Pfluegers Arch. 318: 85 (1970).CrossRefGoogle Scholar
  23. 23.
    Stokely, E. M., Nardizzi, L. R., Parkey, R. W., and Bonte, F. J., Regional myocardial perfusion data with spatial and temporal quantization, J. Nucl. Med. 14: 669 (1973).PubMedGoogle Scholar
  24. 24.
    Horwitz, L. D., Curry, G. C., Parkey, R. W., and Bonte, F. J. Differentiation of physiologically significant coronary artery lesions by coronary blood flow measurements during isoproterenol infusion, Circulation 49: 55 (1974).PubMedCrossRefGoogle Scholar
  25. 25.
    Conti, C. R., Pitt, B., Gundel, W. D., Friesinger, G. C., and Ross, R. S., Myocardial blood flow in pacing-induced angina, Circulation 42: 815 (1970).PubMedCrossRefGoogle Scholar
  26. 26.
    Klocke, F. J., and Wittenberg, S. M., Heterogeneity of coronary blood flow in human coronary artery disease and experimental myocardial infarction, Amer. J. Cardiol. 24: 782 (1969).PubMedCrossRefGoogle Scholar
  27. 27.
    Christensen, E. E., and Bonte, F. J., Radionuclide coronary angiography and myocardial blood flow, Radiology 95: 497 (1970).PubMedGoogle Scholar
  28. 28.
    Bonte, F. J., and Christensen, E. E., Regional myocardial blood flow after experimental myocardial embolization, J. Nucl. Med. 11: 302 (1970).Google Scholar
  29. 29.
    Cannon, P. J., Haft, J. I., and Johnson, P. M., Visual assessment of regional myocardial perfusion utilizing radioactive xenon and scintillation photography, Circulation 40: 277 (1969).PubMedCrossRefGoogle Scholar
  30. 30.
    Cannon, P. J., Dell, R. B., and Dwyer, E. M., Jr., Measurement of regional myocardial perfusion in man with 133-xenon and a sciintillation camera, J. Clin. Invest. 51: 964 (1972).PubMedCrossRefGoogle Scholar
  31. 31.
    Cannon, P. J., Dell, R. B., and Dwyer, E. M., Jr., Regional myocardial perfusion rates in patients with coronary artery disease, J. Clin. Invest. 51: 978 (1972).PubMedCrossRefGoogle Scholar
  32. 32.
    Dwyer, E. M., Jr., Dell, R. B., and Cannon, P. J., Regional myocardial blood flow in patients with residual anterior and inferior transmural infarction, Circulation 48: 924 (1973).PubMedCrossRefGoogle Scholar
  33. 33.
    Bonte, F. J., Parkey, R. W., Stokely, E. M., Lewis, S. E., Horwitz, L. D., and Curry, G. C., Radionuclide determination of myocardial blood flow, Semin. Nucl. Med. 3: 153 (1973).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Robert W. Parkey
    • 1
  • Frederick J. Bonte
    • 1
  • Ernest M. Stokely
    • 1
  • George C. Curry
    • 1
  • James T. Willerson
    • 1
  1. 1.Department of Medicine Southwestern Medical SchoolThe University of Texas Health Science CenterDallasUSA

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