Detection of Left-to-Right Shunts by Inhalation of Oxygen-15-Labeled Carbon Dioxide

  • D. D. Watson
  • P. J. Kenny
  • W. R. Janowitz
  • D. M. Tamer
  • A. J. Gilson
Part of the Topics in Cardiovascular Disease book series (TCAD)


The general properties of 15O-labeled carbon dioxide have been reviewed1,2 and published.3 The most striking property of this gas is that, when inhaled, it causes the sudden labeling of pulmonary venous blood water and, subsequently, a mathematically predictable clearance from the lungs into the left heart. This property, as we will see, can be most useful in the detection and quantitation of left-to-right intracardiac shunts. We will outline the general methods of shunt detection and quantitation here, and with this as background, a method utilizing the special properties of C15O2 inhalation will be developed and demonstrated.


Congenital Heart Disease Right Ventricle Shunt Flow Inhalation Study Intracardiac Shunt 
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • D. D. Watson
    • 1
  • P. J. Kenny
    • 1
  • W. R. Janowitz
    • 1
  • D. M. Tamer
    • 1
  • A. J. Gilson
    • 1
  1. 1.University of Miami School of Medicine, Baumritter Institute of Nuclear MedicineMount Sinai Medical CenterMiami BeachUSA

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