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Role of Radioimmunoassay in the Cardiac Patient—Principles and Applications

  • Fuad S. Ashkar
Part of the Topics in Cardiovascular Disease book series (TCAD)

Abstract

The English physician William Withering introduced digitalis therapy for the management of cardiac disorders around 200 years ago. Although the crude preparations were effective in heart failure, they were accompanied by gastrointestinal upset, visual disturbances, and often death. The dangers associated with digitalis therapy have continued to plague physicians until the present day, since they have had to contend with the narrow margin that exists between beneficial dosage and dosage resulting in toxicity, the variations in tolerance, absorption, excretion, sensitivity, and the lack of a sensitive assay for monitoring the drug blood and tissue levels.

Keywords

Nuclear Cardiology Cardiac Disorder Digoxin Level Digoxin Toxicity Crude Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Ashkar, F. S., Practical Nuclear Medicine, Medcom Press, New York (1974).Google Scholar
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    Doherty, J. E., The clinical pharmacology of digitalis glycosides: A review, Amer. J. Med. Sci. 255: 382 (1968).PubMedCrossRefGoogle Scholar
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    Duhme, D. W., Greenblatt, D. J., and Koch-Weser, J., Reduction of digoxin toxicity associated with measurement of serum levels, Ann. Intern. Med. 80:516 (1974).Google Scholar
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    Smith, T. W., Butler, V. P. Jr., and Harber, E., Determination of therapeutic and toxic serum digoxin concentration by radioimmunoassay, N. Engl. J. Med. 281:1212 (1969).Google Scholar
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    Smith, T. W., and Haver, E., Clinical value of serum digitalis glycoside concentrations in the evaluation of drug toxicity, Ann. N. Y. Acad. Sci. 179: 322 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Fuad S. Ashkar
    • 1
  1. 1.Department of RadiologyUniversity of Miami School of Medicine, Jackson Memorial HospitalMiamiUSA

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