Interaction of Low Density Lipoproteins with Arterial Constituents: Its Relationship with Atherogenesis

  • German Camejo


Atherogenesis appears to be a sequential response of arterial wall cells to injurious stimuli. For many years it has been postulated that plasma low density lipoprotein (LDL) is one of the factors leading to atheromatous lesions.1 Two types of results have supported this hypothesis: one from the demonstration that LDL and some of its components accumulate in the arterial intima media, and the other from follow-up studies of large groups showing that an augmented cholesterol level in plasma is one of the primary risk factors that defines humans with a higher probability of suffering cardiovascular disturbances related to atherosclerosis.2 Smith and Slater3 have provided data that link the immunological and chemical demonstration of LDL components in the arterial wall with the population studies. These authors demonstrated that the amount of detectable LDL in the intima-media of human arteries correlates very well with the circulating levels of plasma LDL. Recently Smith4 presented a valuable review on this subject.


Arterial Wall Cholesteryl Ester Human Aorta Hypercholesterolemic Rabbit Hypercholesterolemic Animal 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • German Camejo
    • 1
  1. 1.Laboratorio de Lipoproteínas, Centro de Biofísica y BioquímicaInstituto Venezolano de Investigaciones Científicas (IVIC)CaracasVenezuela

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