Interaction of Low Density Lipoproteins with Arterial Constituents: Its Relationship with Atherogenesis
Atherogenesis appears to be a sequential response of arterial wall cells to injurious stimuli. For many years it has been postulated that plasma low density lipoprotein (LDL) is one of the factors leading to atheromatous lesions.1 Two types of results have supported this hypothesis: one from the demonstration that LDL and some of its components accumulate in the arterial intima media, and the other from follow-up studies of large groups showing that an augmented cholesterol level in plasma is one of the primary risk factors that defines humans with a higher probability of suffering cardiovascular disturbances related to atherosclerosis.2 Smith and Slater3 have provided data that link the immunological and chemical demonstration of LDL components in the arterial wall with the population studies. These authors demonstrated that the amount of detectable LDL in the intima-media of human arteries correlates very well with the circulating levels of plasma LDL. Recently Smith4 presented a valuable review on this subject.
KeywordsArterial Wall Cholesteryl Ester Human Aorta Hypercholesterolemic Rabbit Hypercholesterolemic Animal
Unable to display preview. Download preview PDF.
- 7.R. W. Wissler, R. E. Tracy, Z. Molnar, D. Racker, M. Mancini, and R. Hughes. 1964. Lipoprotein induced model lesions in the aortic media of rhesus monkeys. Fed. Proc. 23:101.Google Scholar
- 11.Y. Stein and O. Stein. 1973. Lipid synthesis and degradation and lipoprotein transport in mammalian aorta. In: Atherogenesis: Initiating Factors. Ciba Foundation Symp. No. 12 (New Series). Ed. by R. Porter and J. Knight. Assoc. Scientific Publishers, Amsterdam, pp. 165–183.Google Scholar
- 15.S. Eisenberg, Y. Stein, and O. Stein. 1969. Phospholipases in arterial tissue. IV. The role of phosphatide acyl hydrolase, lysophosphatide acyl hydrolase, and sphingomyelin choline phosphohydrolase in the regulation of phospholipid composition in the normal human aorta with age. J. Clin. Invest. 48:2320–2329.PubMedCrossRefGoogle Scholar
- 18.S. Margolis. 1969. Structure of very low and low density lipoproteins. In: Structural and Functional Aspects of Lipoproteins in Living Systems. Ed. by E. Tria and A. M. Scanu. Academic Press, London, pp. 369–424.Google Scholar
- 26.M. Faber. 1949. The human aorta. Sulfate-containing polyuronides and the deposition of cholesterol. Arch. Pathol. 48:342–350.Google Scholar
- 29.P. Bernfeld, J. S. Nisselbaum, B. J. Berkeley, and R. W. Hansen. 1960. The influence of chemical and physico-chemical nature of macromolecular polyanions on their interaction with human beta-lipoproteins. J. Biol. Chem. 235:2852–2859.Google Scholar
- 32.R. W. Jeanloz. 1970. Mucopolysaccharides of higher animals. In: The Carbohydrates. Chemistry and Biochemistry. Volume IIB, 2d ed. Ed. by W. Pigman and D. Horton. Academic Press, New York, pp. 589–625.Google Scholar
- 36.A. Gardais, J. Picard, and B. Hermelin. 1973. Glycosaminoglycan (GAG) distribution in aortic wall from five species. Comp. Biochem. Physiol. 44B:507–515.Google Scholar