The Altered Metabolism of Sialic-Acid-Containing Compounds in Tumorigenic-Virus-Transformed Cells
At this point in time, the quest for information regarding phenomena regulating cell growth has focused to a considerable extent on investigations of alterations in the chemical composition of the surfaces of neoplastic cells. Relatively few discoveries have occurred so far in this regard, but the recently observed alteration of ganglioside composition and the underlying metabolic reactions responsible for this change in tumorigenic-virus-transformed cells may prove to be an important contribution in this area. We shall review the nature of these changes in tumorigenic virus transformation in this chapter. We shall also touch upon some differences in glycoprotein metabolism which have recently been observed in these cells, and we shall make some conclusions regarding the significance of the differences between normal and tumorigenic cells.
KeywordsCarbohydrate Lymphoma Sarcoma Trypsin Butyl
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- Brady, R. O., and Mora, P. T., 1970, Alteration in ganglioside pattern and synthesis in SV40 and polyoma virus transformed mouse cell lines, Biochim. Biophys. Acta 218: 308.Google Scholar
- Diringer, H., Strobel, G., and Koch, M. A., 1972, Glycolipids of mouse fibroblasts and virus transformed mouse cell lines, Hoppe-Seyl. Z. 353: 1759.Google Scholar
- Fishman, P. H., Brady, R. O., and Mora, P. T., 1973, Altered glycolipid metabolism related to viral transformation of established mouse cell lines, in: Tumor Lipids: Biochemistry and Metabolism (R. Wood, ed.), pp. 251–266, American Oil Chemists Society, Chicago.Google Scholar
- Meezan, E., Wu, H. C., Black, P. H., and Robbins, P. W., 1969, Comparative studies on the carbohydrate-containing membrane components of normal and virus-transformed mouse fibroblasts, II. Separation of glycoproteins and glycopeptides by Sephadex chromatography, Biochemistry 8: 2518.PubMedCrossRefGoogle Scholar
- Mora, P. T., 1973, Cell growth regulation, cell selection and the function of the membrane glycolipids, in: Membrane Mediated Information: Function and Biosynthesis of Membrane Lipids and Glycoproteins(P. W. Kent, ed.), pp. 64–84, Oxford University Press, London.Google Scholar
- Mora, P. T., Fishman Bassin, R. H., Brady, R. O., and McFarland, V. W., 1973, Transformation of Swiss 3T3 cells by murine sarcoma virus is followed by decrease in a glycolipid glycosyltransferase, Nature, 2A5: 226.Google Scholar
- Sakiyama, H., and Robbins, P. W., 1973, Glycolipid synthesis and tumorigenicity of clones isolated from the Nil-2 line of hamster embryo fibroblasts, Red. Proc. 32: 86.Google Scholar
- Sheinin, R., Onodera, K., Yogeeswaran, G., and Murray, R. K., 1971, Studies of components of the surface of normal and virus-transformed mouse cells, in: The Biology of Oncogenic Viruses 2nd LePetit Symposium (L. G. Silvestri, ed.), pp. 274–285.Google Scholar
- Weinstein, D. B., Marsh, J. B., Glick, M. C., and Warren, L., 1970, Membranes of animal cells. VI. The glycolipids of the L cell and its surface membrane, J. Biol. Chem. 245: 328.Google Scholar
- Wu, H. C., Meezan, E., Black, P. H., and Robbins, P. W., 1969, Comparative studies on the carbohydrate-containing membrane components of normal and virus-transformed mouse fibroblasts. I. Glucosamine-labeling patterns in 3T3, spontaneously transformed 3T3 and SV40-transformed 3T3 cells, Biochemistry 8: 2509.PubMedCrossRefGoogle Scholar