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From the Growth Cone to the Synapse

Properties of Membranes Involved in Synapse Formation
  • Karl H. Pfenninger
  • Rosemary P. Rees
Part of the Current Topics in Neurobiology book series (CTNB)

Abstract

The development of specific neuronal connections must be based on a set of intricate control mechanisms. The complexity of this fascinating problem results from (1) the enormous number of elements involved (in the human CNS, an estimated 1014 synapses are formed), (2) the long pathway of certain nerve fibers, and (3) the high selectivity of their synaptic connections, not only between and within groups of neurons, but even with regard to the localization of the synapse on an individual postsynaptic cell. Numerous papers (e.g., Sperry, 1944; Attardi and Sperry, 1963; Crossland et al., 1974a; for review, see Gaze, 1970; Jacobson, 1970; Jacobson, this volume) have suggested predetermined, high specificity of synaptic connections. Other experimental work with developing and regenerating parts of the central nervous system (for review, see Jacobson, 1970; Crossland et al., 1974a; Raisman and Field, 1973) as well as studies on synapse formation in vitro (Rees and Bunge, 1974) clearly indicate that the specificity of synaptic connections is not absolute and that it is strictly effective only during a certain period of embryonic development. This suggests that the constellation of neurons—i.e., the availability of certain postsynaptic candidates and the timing of their appearance—in a development brain area may greatly influence the resulting selectivity in synapse formation.

Keywords

Synaptic Vesicle Growth Cone Synaptic Cleft Postsynaptic Density Coated Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Karl H. Pfenninger
    • 1
  • Rosemary P. Rees
    • 2
  1. 1.Section of Cell BiologyYale University School of MedicineNew HavenUSA
  2. 2.Department of AnatomyWashington University School of MedicineSt. LouisUSA

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