Abstract
Morphogenesis of an organ or tissue is a complex and specific series of events leading to a unique, functional organization of cellular and extracellular elements. Underlying these events are several types of cell behavior such as cell movement, recognition and adhesion, shape changes, mitosis, and death. Morphogenesis is usually accompanied by and necessary for cellular differentiation, in which the component cells undergo a series of distinctive metabolic and cytological changes that result in the synthesis or secretion of characteristic and functional cell products. Although morphogenesis and differentiation are not exact or discrete terms (they both involve metabolic, cytological, and behavioral changes), it is the behavioral aspects that are emphasized when morphogenesis is spoken of and the metabolic and cytological changes that are emphasized when differentiation is spoken of.
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References
Anseth, A., 1961, Glycosaminoglycans in the developing corneal stroma, Expl. Eye Res. 1: 116.
Arnott, S., Guss, J. M., Hukins, D. W., and Mathews, M. B., 1973, Mucopolysaccharides: Comparison of chondroitin sulfate conformations with those of related polyanions, Science 180: 743.
Aronson, N. N., and Davidson, E. A., 1967a, Lysosomal hyaluronidase from rat liver. I. Preparations, J. Biol. Chem. 242: 437.
Aronson, N. N., and Davidson, E. A., 1967b, Lysosomal hyaluronidase from rat liver. II. Properties, J. Biol. Chem. 242: 441.
Ashhurst, D. E., and Costin, N. M., 1971, Insect mucosubstances. II. Mucosubstances of the central nervous system, Histochem. J. 3: 297.
Atkins, E. D., Phelps, C. F., and Sheehan, J. K., 1972, The conformation of mucopolysaccharides: Hyaluronates, Biochem. J. 128: 1255.
Atkins, E. D., Hardingham, T. E., Isaac, D. H., and Muir, H, 1974, X-ray fibre diffraction of cartilage proteoglycan aggregates containing hyaluronic acid, Biochem. J. 141: 919.
Bernfield, M. R., 1970, Collagen synthesis during epithelio-mesenchymal interactions, Dep. Biol. 22: 213.
Bemfield, M. R., and Banerjee, S. D., 1972, Acid mucopolysaccharide (glycosaminoglycan) at the epithelial-mesenchymal interface of mouse embryo salivary glands, J. Cell Biol. 52: 664.
Bemfield, M. R., Banerjee, S. D., and Cohn, R. H., 1972, Dependence of salivary epithelial morphology and branching morphogenesis upon acid mucopolysaccharide-protein (proteoglycan) at the epithelial surface, J. Cell Biol. 52: 674.
Bernfield, M. R., Cohn, R. H., and Banerjee, S. D., 1973, Glycosaminoglycans and epithelial organ formation, Am. Zool. 13: 1067.
Bondareff, W., and Narotsky, R., 1972, Age changes in the neuronal microenvironment, Science 176: 1135.
Bondareff, W., and Pysh, J. J., 1968, Distribution of the extracellular space during postnatal maturation of rat cerebral cortex, Anat. Rec. 160: 773.
Bradbury, M. W., Villamil, M., and Kleiman, C. R., 1968, Extracellular fluid, ionic distribution and exchange in isolated frog brain, Am. J. Physiol. 214: 643.
Breen, M., Weinstein, H. G., Johnson, R. L., Veis, A., and Marshall, R. T., 1970, Acidic glycosaminoglycans in human skin during fetal development and adult life, Biochim. Biophys. Acta 201: 54.
Breen, M., Johnson, R. L., Sittig, R. A., Weinstein, H. G., and Veis, A., 1972, The acidic glycosaminoglycans in human fetal development and adult life: Cornea, sclera and skin, Connect. Tissue Res. 1: 291.
Burger, M. M., and Martin, G. S., 1972, Agglutination of cells transformed by Rous sarcoma virus by wheat germ agglutinin and concanavalin A, Nature (London) New Biol. 237: 9.
Chalkley, D. T., 1959, The cellular basis of limb regeneration, in: Regeneration in Vertebrates (C. S. Thornton, ed.), pp. 34–58, University of Chicago Press, Chicago. Clarris, B. J., and Fraser, J. R., 1968, On the pericellular zone of some mammalian cells ivitro, Exp. Cell Res. 49: 181.
Cleland, R. L., 1970, Molecular weight distribution in hyaluronic acid, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 ( E. A. Balazs, ed.), pp. 733–742, Academic Press, New York.
Comper, W. D., and Preston, B. N., 1974, Model connective tissue systems: A study of polyion-mobile ion and of excluded-volume interactions of proteoglycans, Biochem. J. 143: 1.
Conrad, G. W., 1970, Collagen and mucopolysaccharide biosynthesis in the developing chick cornea, Dev. Biol. 21: 292.
Coulombre, A. J., and Coulombre, J. L., 1958, Corneal development. I. Corneal transparency, J. Cell. Comp. Physiol. 51: 1.
Coulombre, A. J., and Coulombre, J. L., 1964, Corneal development. III. The role of the thyroid in dehydration and the development of transparency, Exp. Eye Res. 3: 105.
Custod, J. T., and Young, I. J., 1968, Cat brain mucopolysaccharides and their in vivo hyaluronidase digestion, J. Neurochem. 15: 809.
Darzynkiewicz, A., and Balazs, E. A., 1971, Effect of connective tissue intercellular matrix on lymphocyte stimulation. I. Suppresion of lymphocyte stimulation by hyaluronic acid, Exp. Cell Res. 66: 113.
Davidson, E. A., 1970, Glycoprotein and mucopolysaccharide hydrolysis, in: Metabolic Conjugation and Metabolic Hydrolysis, Vol. 1, ( W. H. Fishman, ed.), pp. 327–353, Academic Press, New York.
Dea, I. C., Moorhouse, R., Rees, D. A., Amott, S., Guss, J. M., and Balazs, E. A., 1973, Hyaluronic acid: A novel, double helical molecule, Science 179: 560.
DeLuca, S., Richmond, M. E., and Silbert, J. E., 1973, Biosynthesis of chondroitin sulfate: Sulfation of the polysaccharide chain, Biochemistry 12: 3911.
DeSouza, S. W., and Dobbing, J., 1971, Cerebral edema in developing brain. 1. Normal water and cation content in developing rat brain and postmortem changes,Exp. Neurol. 32: 431.
Dingle, J. T., and Webb, M., 1965, Mucopolysaccharide metabolism in tissue culture, in: Cells and Tissues in Culture, Vol. 1 ( E. N. Willmer, ed.), pp. 353–396, Academic Press, New York.
Dingle, J. T., Barrett, A. J., and Weston, P. D., 1971, Cathepsin D—Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown, Biochem. J. 123: 1.
Disalvo, J., and Schubert, M., 1966, Interaction during fibril formation of soluble collagen with cartilage protein polysaccharide, Biopolymers 4: 247.
Dorner, R. W., 1968, Changes in glycosaminoglycan composition associated with maturation of regenerating rabbit tendon, Arch. Biochem. Biophys. 128: 34.
Dunstone, J. R., 1962, Ion-exchange reactions between acid mucopolysaccharides and various cations, Biochem. J. 85: 336.
Eisenstein, R., Larsson, S., Sorgente, N., and Kuettner, K. E., 1973, Collagen-proteoglycan relationships in epiphyseal cartilage, Am. J. Pathol. 73: 443.
Ellison, M. L., and Lash, J. W., 1971, Environmental enhancement of in vitro chondrogenesis, Dev. Biol. 26: 486.
Fessier, J., 1960, A structural function of mucopolysaccharide in connective tissue, Biochem. J. 76: 124.
Finch, R. A., and Zwilling, E., 1971, Culture stability of morphogenetic properties of chick limb-bud mesoderm, J. Exp. Zool. 176: 397.
Fransson, L. A., 1970, Structure and metabolism of the proteoglycans of dermatan sulfate, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 ( E. A. Balazs, ed.), pp. 823–842, Academic Press, New York.
Fraser, J. R., Clarris, F. J., and Kont, L. A., 1970, The morphology and motility of human synovial cells and their pericellular gels: A time-lapse microcinematographic study, Aust. J. Biol. Sci. 23: 1297.
Gerber, B. R., and Schubert, M., 1964, The exclusion of large solutes by cartilage protein polysaccaride, Biopolymers 2: 259.
Goetinck, P. F., Pennypacker, J. P., and Royal, P. D., 1974, Proteochondroitin sulfate synthesis and chondrogenic expression, Exp. Cell Res. 87: 241.
Goggins, J. F., Johnson, G. S., and Pastan, I., 1972, The effect of dibutyryl cyclic adenosine monophosphate on synthesis of sulfated acid mucopolysaccharides by transformed cells, J. Biol. Chem. 247: 5759.
Gona, A. G., 1973, Effects of thyroxine, thyrotropin, prolactin, and growth hormone on the maturation of the frog cerebellum, Exp. Neurol. 38: 494.
Gordon, J. S., and Lash, J. W., 1974, In vitro chondrogenesis and cell viability, Dev. Biol. 36: 88.
Gregory, J. D., 1973, Multiple aggregation factors in cartilage proteoglycan, Biochem. J. 133: 383.
Grillo, H. C., Lapiere, C. M., Dresden, M. H., and Gross, J., 1968, Collagenolytic activity in regenerating forelimbs of the adult newt (Triturus viridescens), Dev. Biol. 17: 571.
Grobstein, C., 1967, Mechanisms of organogenetic tissue interaction, Natl. Cancer Inst. Monogr. 26: 279.
Grobstein, C., and Cohen, J., 1965, Collagenase: Effect on the morphogenesis of embryonic salivary epithelium in vitro, Science 150: 626.
Hamburger, F., and Hamilton, H. L., 1951, A series of normal stages in the development of the chick embryo, J. Morphol. 88: 49.
Hamburgh, M., Mendoza, L. A., Burkart, J. F., and Weil, F., 1971, in: Hormones in Development (M. Hamburgh and E. J. Barrington, eds.), pp. 403–415, AppletonCentury-Crofts, New York.
Hanaway, J., 1967, Formation and différentiation of the external granular layer of the chick cerebellum, J. Comp. Neurol. 131: 1.
Hardingham, T. E., and Muir, H., 1972, The specific interaction of hyaluronic acid with cartilage proteoglycans, Biochim. Biophys. Acta 279: 401.
Hardingham, T. E., and Muir, H., 1974, Hyaluronic acid in cartilage and proteoglycan aggregation, Biochem. J. 139: 565
Hascall, V. C., and Heinegard, D., 1974a, Aggregation of cartilage proteoglycans. I. The role of hyaluronic acid, J. Biol. Chem. 249: 4232.
Hascall, V. C., and Heinegard, D., 1974b, Aggregation of cartilage proteoglycans. II. Oligosaccharide competitors of the proteoglycan-hyaluronic acid interaction, J. Biol. Chem. 249: 4242.
Hascall, V. C., and Heinegard, D., 1975, The structure of cartilage proteoglycans, in: Extracellular Matrix Influences on Gene Expression ( H. C. Slavkin and R. Greulich, eds.), pp. 423–434, Academic Press, New York.
Hascall, V. C., and Sajdera, S. W., 1970, Physical properties and polydispersity of proteoglycan from bovine nasal cartilage, J. Biol. Chem. 245: 4920.
Hay, E. D., 1966a, Regeneration, Holt, Rinehart and Winston, New York.
Hay, E. D., 1966b, Embryologic origin of tissues, in: Histology ( R. O. Greep, ed.), pp. 5673, McGraw-Hill, New York.
Hay, E. D., 1968, Dedifferentiation and metaplasia in vertebrate and invertebrate regeneration, in: Stability of the Differentiated State ( H. Ursprung, ed.), pp. 85–108, Springer, New York.
Hay, E. D., 1970, Regeneration of muscle in the amputated amphibian limb, in: Regeneration of Striated Muscle, and Myogenesis ( A. Mauro, S. A., Shafiq, and A. T. Milhorat. eds), pp. 3–24, Excerpta Medica, Amsterdam.
Hay, E. D., 1973, Origin and role of collagen in the embryo, Am. Zool. 13: 1085.
Hay, E. D., and Meier, S., 1974, Glycosaminoglycan synthesis by embryonic inductors: Neural tube, notochord, and lens, J. Cell Biol. 62: 889.
Hay, E. D., and Revel, J. P., 1969, Fine Structure of the Developing Avian Cornea (A. Wolsky and P. S. Chem, eds.), Vol. I of Monographs in Developmental Biology, Karger, Basel.
Heersche, J. N., Marcus, R., and Aurbach, G. D., 1974, Calcitonin and the formation of 3’, 5’-AMP in bone and kidney, Endocrinology 94: 241.
Heinegard, D., and Hascall, V. C., 1974, Aggregation of cartilage proteoglycans. III. Characteristics of the proteins isolated from trypsin digests of aggregates, J. Biol. Chem. 249: 4250.
Hirano, S., and Meyer, K., 1971, Enzymatic degradation of corneal and cartilagenous keratosulfates, Biochem. Biophys. Res. Commun. 44: 1371.
Hopwood, J. J., Fitch, F. W., and Dorfman, A., 1974, Hyaluronic acid synthesis in a cell- free system from rat fibrosarcoma, Biochem. Biophys. Res. Commun. 61: 583.
Hovingh, P., and Linker, A., 1970, The enzymatic degradation of heparin and heparitin sulfate. III. Purification of a heparitinase and a heparinase from flavobacteria, J. Biol. Chem. 245: 6170.
Huffer, E. S., 1970, Glycosaminoglycans in the cartilage of developing chick embryo limbs, Calc. Tissue Res. 6: 55.
Immers, J., 1961, Comparative study of the localization of incorporated “C-labeled amino acids and 35504 in the sea urchin ovary, egg and embryo, Exp. Cell Res. 24: 356.
Immers, J., and Runnstrom, J., 1965, Further studies of the effects of deprivation of sulfate on the early development of the sea urchin Paracentrosus lividus, J. Embryol. Exp. Morphol. 14: 289.
Ishimoto, N., Temin, H. M., and Strominger, J. L., 1966, Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts, J. Biol. Chem. 241: 2052.
Iwata, H., and Urist, M. R., 1973, Hyaluronic acid production and removal during bone morphogenesis in implants of bone matrix in rats, Clin. Orthop. Rel. Res. 90: 236.
Jacobson, M., 1970, Developmental Neurobiology, Holt, Rinehart and Winston, New York. Kallman, F., and Grobstein, C., 1965, Source of collagen at epitheliomesenchymal interfaces during inductive interaction, Dev. Biol. 11: 169.
Karp, G. C., and Solursh, M., 1974, Acid mucopolysaccharide metabolism, the cell surface, and primary mesenchyme cell activity in the sea urchin embryo, Dev. Biol. 41: 110.
Katchalsky, A., 1964, Polyelectrolytes and their biological interactions, Biophys. J. Suppl. 4: 9.
Kempson, G. E., Muir, H., Swanson, S. A., and Freeman, M. A., 1970, Correlations between stiffness and the chemical constituents of cartilage on the human femoral head, Biochim. Biophys. Acta 215: 70.
Kinoshita, S., 1969, Periodical release of heparin-like polysaccharide within cytoplasm during cleavage of sea urchin egg, Exp. Cell Res. 56: 39.
Kojima, K., and Yamagata, T., 1971, Glycosaminoglycans and electrokinetic behavior of rat ascites hepatoma cells, Exp. Cell Res. 67: 142.
Kollros, J. J., and McMurray, V. M., 1956, The mesencephalic V nucleus in anurans. II. The influence of thyroid hormone on cell size and cell number, J. Exp. Zool. 131: 1.
Konigsberg, I. R., 1970, The relationship of collagen to the clonal development of embryonic skeletal muscle, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 3 ( E. A. Balazs, ed.), pp. 1779–1810, Academic Press, New York.
Kosher, R. A., and Searls, R. L., 1973, Sulfated mucopolysaccharide synthesis during the development of Rana pipiens, Dev. Biol. 32: 50.
Kosher, R. A., Lash, J. W., and Minor, R. R., 1973, Environment enhancement of in vitro chondrogenesis. IV. Stimulation of somite chondrogenesis by exogenous chondromucoprotein, Dev. Biol. 35: 210.
Kraemer, P. M., 1971a, Heparan sulfates of cultured cells. I. Membrane associated and cell-sap species in Chinese hamster cells, Biochemistry 10: 1437.
Kraemer, P. M., 1971b, Heparan sulfates of cultured cells. II. Acid-soluble and precipitable species of different cell lines, Biochemistry 10: 1445.
Kraemer, P. M., and Tobey, R. A., 1972, Cell-cycle dependent desquamation of heparan sulfate from the cell surface, J. Cell Biol. 55: 713.
Krusius, T., Finne, J., Karkkainen, J., and Jamefelt, J., 1974, Neutral and acidic glycopeptides in adult and developing rat brain, Biochim. Biophys. Acta 365: 80.
Kvist, T. N., and Finnegan, C. V., 1970a, The distribution of glycosaminoglycans in the axial region of the developing chick embryo. I. Histochemical analysis, J. Exp. Zool. 175: 221.
Kvist, T. N., and Finnegan, C. V., 1970b, The distribution of glycosaminoglycans in the axial region of the developing chick embryo. II. Biochemical analysis, J. Exp. Zool. 175: 241.
Lash, J. W., 1968, Chondrogenesis: Genotypic and phenotypic expression. J. Cell. Physiol. 72:Suppl. 1, 35–46.
Lash. J. W., and Kosher, R. A., 1975, Perinotochordal proteoglycans and somite chondrogenesis, in: Extracellular Matrix Influences on Gene Expression ( H. C. Slavkin and R. Greulich, eds.), pp. 671–676, Academic Press, New York.
Lash, J., Holtzer, S., and Holtzer, H., 1957, An experimental analysis of the development of the spinal column, Exp. Cell Res. 13: 292.
Laurent, T. C., 1964, The interaction between polysaccharides and other macromolecules. 9. The exclusion of molecules from hyaluronic acid gels and solutions, Biochem. J. 93: 106.
Laurent, T. C., 1966, In vitro studies on the transport of macromolecules through the connective tissue, Fed. Proc. 25: 1128.
Laurent, T. C., 1970, Structure of hyaluronic acid, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 ( E. A. Balazs, ed.), pp. 703–732. Academic Press, New York.
Laurent, T. C., and Ogston, A. G., 1963, The interaction between polysaccharides and other macromolecules. 4. The osmotic pressure of mixtures of serum albumin and hyaluronic acid, Biochem. J. 89: 249.
Laurent, T. C., Ryan, M., and Pietruszkiewicz, A., 1960, Fractionation of hyaluronic acid: The polydispersity of hyaluronic acid from the bovine vitreous body, Biochim. Biophys. Acta 42: 476.
Laurent, T. C., Bjork, I., Pietruskiewicz, A., and Persson, H., 1963, On the interaction between polysaccarides and other macromolecules. II. The transport of globular particles through hyaluronic acid solutions, Biochim. Biophys. Acta 78: 351.
LaVail, J. H., and Cowan, W. M., 1971a, The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development, Brain Res. 28: 391.
LaVail, J. H., and Cowan, W. M., 1971b, The development of the chick optic tectum. II. Autoradiographic studies, Brain Res. 28: 421.
LeGrand, J., 1971, Comparative effects of thyroid deficiency and undernutrition on maturation of the nervous system and particularly on myelination in the young rat, in: Hormones in Development ( M. Hamburgh and E. J., Barrington, eds.), pp. 381–390 Appleton-Century-Crofts, New York.
Levey, G. S., and Epstein, S. E., 1969, Myocardial adenylcyclase: Activation by thyroid hormone and evidence for two adenyl cyclase systems, J. Clin. Invest. 48: 1663.
Levitt, D., and Dorfman, A., 1974, Concepts and mechanisms of cartilage differentiation, in: Current Topics in Development Biology, Vol. 8 ( A. Moscona, ed.), pp. 103–149, Academic Press, New York.
Lindahl, U., 1970, Structure of heparin, heparan sulfate and their proteoglycans, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 ( E. A. Balazs, ed.), pp. 943–960, Academic Press, New York.
Linsenmayer, T. F., 1974, Temporal and spatial transitions in collagen types during embryonic chick limb development. II. Comparison of the embryonic cartilage collagen molecule with that from adult cartilage, Dev. Biol. 40: 372.
Linsenmayer, T. F., Trelstad, R. L., Toole, B. P., and Gross, J., 1973a, The collagen of osteogenic cartilage in the embryonic chick, Biochem. Biophys. Res. Commun. 52: 870.
Linsenmayer, T. F., Toole, B. P., and Trelstad, R. L., 1973b, Temporal and spatial transitions in collagen types during embryonic chick limb development, Dev. Biol. 35: 232.
Lippman, M., 1968, Glycosaminoglycans and cell division, in: Epithelial—Mesenchymal Interactions ( R. Fleischmajer and R. E. Billingham, eds.), pp. 208–229, Williams and Wilkins, Baltimore.
Lipson, M. J., Cerskus, R. A., and Silbert, J. E., 1971, Glycosaminoglycans and glycosaminoglycan degrading enzyme of Rana catesbeiana back skin during late stages of metamorphosis, Dev. Biol. 25: 198.
Loewi, G., and Meyer, K., 1958, The acid mucopolysaccharides of embryonic skin, Biochim. Biophys. Acta 27: 453.
Lowther, D. A., Preston, B. N., and Meyer, F. A., 1970, Isolation and properties of chondroitin sulphates from bovine heart valves, Biochem. J. 118: 595.
Makita, A., and Shimojo, H., 1973, Polysaccarides of SV40-transformed green monkey kidney cells, Biochim. Biophys. Acta 304: 571.
Manasek, F. J., Reid, M., Vinson, W., Seyer, J., and Johnson, R., 1973, Glycosaminoglycan synthesis by the early embryonic chick heart, Dev. Biol. 35: 332.
Marcus, R., 1975, Cyclic nucleotide phosphodiesterase from bone: Characterization of the enyzyme and studies of inhibition by thyroid hormones, Endocrinology 96: 400.
Margolis, R. U., 1967, Acid mucopolysaccharides and proteins of bovine whole brain
Margolis, R. U., and Atherton, D. M., 1972, The heparan sulfate of rat brain, Biochim. Biophys. Acta 273: 368.
Margolis, R. U., and Margolis, R. K., 1974, Distribution and metabolism of mucopolysaccharides and glycoproteins in neuronal perikarya, astrocytes and oligodendroglia, Biochemistry 13: 2849.
Margolis, R. U., Margolis, R. K., Chang, L. B., and Preti, C., 1975, Glycosaminoglycans of brain during development, Biochemistry 41: 85.
Markwald, R. R., and Adams-Smith, W. N., 1972, Distribution of mucosubstances in the developing rat heart, J. Histochem. Cytochem. 20: 896.
Martin, T. J., Harris, G. S., Melick, R. A., and Fraser, J. R., 1969, Effect of calcitonin on glycosaminoglycan synthesis of embryo calf bone cells in vitro, Experientia 25: 375.
Mathews, M. B., 1965, The interaction of collagen and acid mucopolysaccharides: A model for connective tissue, Biochem. J. 96: 710.
Mathews, M. B., and Decker, L., 1968, The effect of acid mucopolysaccarides and acid mucopolysaccharide-proteins on fibril formation from collagen solutions, Biochem. J. 109: 517.
Maurer, P. H., and Hudack, S. S., 1952, Isolation of hyaluronic acid from callus tissue during early healing, Arch. Biochem. 38: 49.
Medoff, J., 1967, Enzymatic events during cartilage differentiation in the chick embryonic limb bud, Dev. Biol. 16: 118.
Meier, S., and Hay, E. D., 1973, Synthesis of sulfated glycosaminoglycans by embryonic corneal epithelium, Dev. Biol. 35: 318.
Meier, S., and Hay, E. D., 1974, Stimulation of extracellular matrix synthesis in the developing cornea by glycosaminoglycans, Proc. Natl. Acad. Sci. USA 71: 2310.
Meier, S., and Solursh, M., 1973, Mediation of growth hormone-enhanced expression of the cartilage phenotype in vitro by the availability of the essential amino acid valine, Dev. Biol. 30: 290.
Meyer, K., Hoffman, P., and Linker, A., 1960, Hyaluronidases, in: The Enzymes, Vol. 4 ( P. D. Boyer, H. Lardy, and K. Myrback, eds.), pp. 447–460, Academic Press, New York.
Meyer, F. A., Preston, B. N., and Lowther, D. A., 1969, Isolation and properties of hyaluronic acid from bovine heart valves, Biochem. J. 113: 559.
Meyer, F. A., Comper, W. D., and Preston, B. N., 1971, Model connective tissues systems: A physical study of gelatin gels containing proteoglycans, Biopolymers 10: 1351.
Minns, R. J., Soden, P. D., and Jackson, D. S., 1973, The role of the fibrous components and ground substance in the mechanical properties of biological tissues: A preliminary investigation, J. Biomech. 6: 153.
Morris, C. C., 1960, Quantitative studies on the production of acid mucopolysaccharides by replicate cell cultures of rat fibroblasts, Ann. N.Y. Acad. Sci. 86: 878.
Morris, C. C., and Godman, G. C., 1960, Production of acid mucopolysaccharides by fibroblasts in cell cultures, Nature (London) 188: 407.
Moscatelli, D., and Rubin, H., 1975, Increased hyaluronic acid production on stimulation of DNA synthesis in chick embryo fibroblasts, Nature (London) 254: 65.
Moscona, A. A., 1960, Patterns and mechanisms of tissue reconstruction from dissociated cells, in: Developing Cell Systems and Their Control ( D. Rudnick, ed.), pp. 45–70, Ronald Press, New York.
Moscona, A. A., 1961, Rotation-mediated histogenetic aggregation of dissociated cells: A quantifiable approach to cell interactions in vitro, Exp. Cell Res. 22: 455.
Moskowitz, J., and Fain, J. N., 1970, Stimulation by growth hormone and dexamethasone of labelled cyclic adenosine 3’,5’-monophosphate accumulation by white fat cells, J. Biol. Chem. 245: 1101.
Muir, H., 1969, The structure and metabolism of mucopolysaccharides (glycosaminoglycans) and the problem of the mucopolysaccharidoses, Am. J. Med. 47: 673.
Mustafa, M., and Kamat, D. N., 1973, Mucopolysaccharide histochemistry of Musca domestica. VII. The brain, Acta Histochem. 45: 254.
Nakao, K., and Bashey, R. I., 1972, Fine structure of collagen fibrils as revealed by ruthenium red, Exp. Mol. Pathol. 17: 6.
Nanto, V., 1969, Electrophoretic analysis of acidic glycosaminoglycans and its application to the developing chick embryo, Ann. Acad. Sci. Fenn. Ser. AS (Medica) 144: 1.
Nemeth-Csoka, M., 1970, Importance of sulphated acid mucopolysaccharides for fibrillogenesis in carrageenin granulomata of rats at different ages, Exp. Gerontol. 5: 67.
Neufeld, E. F., 1974, The biochemical basis for mucopolysaccharidoses and mucolipidoses, in: Progress in Medical Genetics, Vol. 10 ( A. G. Steinberg and A. G. Beam, eds.), pp. 81–101, Grune and Stratton, New York.
Nevis, A. H., and Collins, G. H., 1967, Electrical impedance and volume changes in brain during development, Brain Res. 5: 57.
Nevo, Z., and Dorfman, A., 1972, Stimulation of chondromucoprotein synthesis in chondrocytes by extracellular chondromucoprotein, Proc. Natl. Acad. Sci. USA 69: 2069.
Obrink, B., 1972, Isolation and partial characterization of a dermatan sulfate proteoglycan from pig skin, Biochim. Biophys. Acta 264: 354.
Obrink, B., 1973a, A study of the interactions between monomeric tropocollagen and glycosaminoglycans, Eur. J. Biochem. 33: 387.
Obrink, B., 1973b, The influence of glycosaminoglycans on the formation of fibers from monomeric tropocollagen in vitro, Eur. J. Bioch. 34: 129.
Ogston, A. G., 1966, On water binding, Fed. Proc. 25: 986.
Ogston, A. G., 1970, The biological functions of the glycosaminoglycans, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 3 (E. A. Balazs, ed.), pp. 12311240, Academic Press, New York.
Ogston, A. G., and Phelps, C. F., 1961, The partition of solutes between buffer solutions and solutions containing hyaluronic acid, Biochem. J. 78: 827.
Ogston, A. G., and Sherman, T. F., 1961, Effects of hyaluronic acid upon diffusion of solutes and flow of solvent, J. Physiol. (London) 156: 67.
Ogston, A. G., and Stanier, J. E., 1953, The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties, J. Physiol. (London) 119: 244.
Ohya, T., and Kaneko, Y., 1970, Novel hyaluronidase from Streptomyces, Biochim. Biophys. Acta 198: 607.
Palmoski, M. J., and Goetinck, P. F., 1972, Synthesis of proteochondroitin sulfate by normal, nanomelic and 5-bromodeoxyuridine-treated chondrocytes in cell culture, Proc. Natl. Acad. Sci. USA 69: 3385.
Palmoski, M., Khosla, R., and Brandt, K., 1974, Small proteoglycans of cartilage: Confirmation of their presence by non-disruptive extraction, Biochim. Biophys. Acta 372: 171.
Pawelek, J. M., 1969, Effects of thyroxine and low oxygen tension on chondrogenic expression in cell culture, De?). Biol. 19: 52.
Pesetsky, I., 1966, The role of the thyroid in the development of Mauthner’s neuron: A karyometric study in thyroidectomized anuran larvae, Z. Zellforsch. 75:138. Pessac, B., and Defendi, V., 1972, Cell aggregation: Role of acid mucopolysaccharides, Science 175: 898.
Podrazky, V., Steven, F. S., Jackson, D. S., Weiss, J. B., and Leibovich, S. J., 1971, Interaction of tropocollagen with protein polysaccharide complexes: An analysis of the ionic groups responsible for interaction, Biochim. Biophys. Acta 229: 690.
Polansky, J., and Toole, B. P., 1975, unpublished results.
Polansky, J., Toole, B. P., and Gross, J., 1974, Brain hyaluronidase: Changes in activity during chick development, Science 183: 862.
Pratt, R. M., Larsen, M. A., and Johnston, M. C., 1975, Migration of cranial neural crest cells in a cell-free hyaluronate-rich matrix, Dev. Biol. 44: 298–305.
Praus, R., and Brettschneider, I., 1970, Presence of a non-sulphated glucosaminoglycan in embryonic cornea, FEBS Lett. 6: 221.
Praus, R., and Brettschneider, I., 1971, Glycosaminoglycans in the developing chicken cornea, Ophthalmol. Res. 2: 367.
Preston, B. N., and Snowden, J. M., 1972, Model connective tissue systems: The effect of proteoglycans on the diffusional behavior of small non-electrolytes and microions, Biopolymers 11: 1627.
Preston, B. N., Davies, M., and Ogston, A. G., 1965, The composition and physicochemical properties of hyaluronic acids prepared from ox synovial fluid and from a case of mesothelioma, Biochem. J. 96: 449.
Quintarelli, G., Vocaturo, A., Bellocci, M., Roden, L., Iffolito, E., and Baker, J. R., 1974, Preliminary ultrastructural demonstration of hyaluronic acid-proteoglycan interaction in cartilage matrix, Am. J. Anat. 140: 433.
Reid, T., and Flint, M. H., 1974, Changes in glycosaminoglycan content of healing rabbit tendon, J. Embryol. Exp. Morphol. 31: 489.
Rienits, K. G., 1960, The acid mucopolysaccharides of the sexual skin of apes and monkeys, Biochem. J. 74: 27.
Robinson, H. C., Telser, A., and Dorfman, A., 1966, Studies on biosynthesis of the linkage region of chondroitin sulfate-protein complex, Proc. Natl. Acad. Sci. 56: 1859.
Roblin, R., Albert, S. O., Gelb, N. A., and Black, P. H., 1975, Cell surface changes correlated with density-dependent growth inhibition: Glycosaminoglycan metabolism in 3T3, SV3T3, and Con A selected revertant cells, Biochemistry 14: 347.
Roden, L., 1970a, The structure and metabolism of the proteoglycans of chondroitin sulfates and keratan sulfate, in: Chemistry and Molecular Biology of the Intercellular Matrix Vol. 2 ( E. A. Balazs, ed.), pp. 797–821, Academic Press, New York.
Roden, L., 1970b, Biosynthesis of acidic glycosaminoglycans (mucopolysaccharides), in: Metabolic Conjugation and Metabolic Hydrolysis, Vol. 2 ( W. H. Fishman, ed.), pp. 345–442, Academic Press, New York.
Rosenberg, L., Hellmann, W., and Kleinschmidt, A. K., 1970, Macromolecular models of protein polysaccarides from bovine nasal cartilage based on electron microscopic studies, J. Biol. Chem. 245: 4123.
Saito, H. Yamagata, T., and Suzuki, S., 1968, Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates, J. Biol. Chem. 243: 1536.
Sajdera, S. W., and Hascall, V. C., 1969, Proteinpolysaccharide complex from bovine nasal cartilage: A comparison of low and high shear extraction procedures, J. Biol. Chem. 244: 77.
Sajdera, S. W., Hascall, V. C., Gregory, J. D., and Dziewiatkowski, D. D., 1970, The proteoglycans of bovine nasal cartilage: Structure of the aggregate, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 ( E. A. Balazs, ed.), pp. 851–858, Academic Press, New York.
Samuels, H. H., and Tsai, J. S., 1973, Thyroid hormone action in cell culture: Demonstration of nuclear receptors in intact cells and isolated nuclei, Proc. Natl. Acad. Sci. 70: 3488.
Sapolsky, A. I., Howell, D. S., and Woessner, J. F., 1974, Neutral proteases and cathepsin D in human articular cartilage, J. Clin. Invest. 53: 1044.
Satoh, C., Duff, R., Rapp, F., and Davidson, E. A., 1973, Production of mucopolysaccharides by normal and transformed cells, Proc. Natl. Acad. Sci. 70: 54.
Schacter, L. P., 1970, Effect of conditioned media on differentiation in mass cultures of chick limb bud cells. I. Mophological effects, Exp. Cell Res. 63: 19.
Schiller, S., Slover, G. A., and Dorfman, A., 1962, Effect of the thyroid gland on metabolism of acid mucopolysaccharides in skin, Biochim. Biophys. Acta 58: 27.
Schubert, M., and Hamerman, D., 1964, The functioning of the diffuse macromolecules of joints, Bull. Rheum. Dis. 14: 345.
Schubert, M., and Hammerman, D., 1968, A Primer on Connective Tissue Biochemistry, Lea and Febiger, Philadelphia.
Schwartz, N. B., Roden, L., and Dorfman, A., 1974, Biosynthesis of chondroitin sulfate: Interaction between xylosyltransferase and galactosyltransferase, Biochem. Biophys. Res. Commun. 56: 717.
Schwartz, N. B., Dorfman, A., and Roden, L., 1975, Role of enzyme—enzyme interactions in the organization of multi—enzyme systems, in: Extracellular Matrix Influences on Gene Expression ( H. C. Slavkin and R. Greulich, eds.), pp. 197–208, Academic Press, New York.
Scott, J. E., 1968, Ion binding in solutions containing acid mucopolysaccharides, in: The Chemical Physiology of Mucopolysaccharides ( G. Quintarelli, ed.), pp. 171–187, Little, Brown, Boston,.
Searls, R. L., 1965, An autoradiographic study of the uptake of S’-sulfate during the differentiation of limb bud cartilage, Dep. Biol. 11: 155.
Searls, R. L., and Janners, M. Y., 1969, The stabilization of cartilage properties in the cartilage-forming mesenchyme of the embryonic chick limb, J. Exp. Zool. 170: 365.
Serafini-Fracassini, A., Wells, P. J., and Smith, J. W., 1970, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 2 (E. A. Balazs, ed.), pp. 1201–1215, Academic Press, New York.
Sidman, R. L., and Rakic, P., 1973, Neuronal migration with special reference to developing human brain: A review, Brain Res. 62: 1.
Silbert, J. E., and DeLuca, S., 1970, Degradation of glycosaminoglycans by tadpole tissue: Differences in activity toward chondroitin 4-sulfate and chondroitin 6-sulfate, J. Biol. Chem. 245: 1506.
Silpananta, P., Dunstone, J. R., and Ogston, A. G., 1968, Fractionation of a hyaluronic acid preparation in a density gradient: Some properties of the hyaluronic acid, Biochem. J. 109: 43.
Singer, M., and Craven, L., 1948, The growth and morphogenesis of the regenerating forelimb of adult Triturus following denervation at various stages of development, J. Exp. Zool. 108: 279.
Singh, M., and Bacchawat, B. K., 1965, The distribution and variation with age of different uronic acid-containing mucopolysaccharides in brain, J. Neurochem. 12: 519.
Singh, M., and Bacchawat, B. K., 1968, Isolation and characterization of glycosaminoglycans in human brain of different age groups, J. Neurochem. 15: 249.
Singh, M., Chandrasekaran, E. V., Cherian, R., and Bacchawat, B. K., 1969, Isolation and characterization of glycosaminoglycans in brain of different species, J. Neurochem. 16: 1157.
Sissons, H. A., 1971, The growth of bone, in: The Biochemistry and Physiology of Bone, Vol. 3 ( G. H. Bourne, ed.), pp. 145–180, Academic Press, New York.
Smith, G. N., Toole, B. P., and Gross, J., 1975, Hyaluronidase activity and glycosaminoglycan synthesis in the amputated newt limb: Comparison of denervating, non-regenerating limbs with regenerates, Dev. Biol. 43: 221–232.
Smith, J. W., and Frame, J., 1969, Observations on the collagen and protein—polysaccharide complex of rabbit corneal stroma, J. Cell Sci. 4: 421.
Solursh, M., Vaerewyck, S. A., and Reiter, R. S., 1974, Depression by hyaluronic acid of glycosaminoglycan synthesis by cultured chick embryo chondrocytes, Dev. Biol. 41: 233.
Steinberg, M. S., 1970, Does differential adhesion govern the self-assembly of tissue structure? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells, J. Exp. Zool. 173: 395.
Stoolmiller, A. C., and Dorfman, A., 1969, The biosynthesis of hyaluronic acid by Streptococcus, J. Biol. Chem. 244: 236.
Sugiyama, K., 1972, Occurrence of mucopolysaccharides in the early development of the sea urchin embryo and its role in gastrulation, Dev. Growth Differ. 14: 63.
Suzuki, S., Kojima, K., and Utsumi, K. R., 1970, Production of sulfated mucopolysaccharides by established cell lines of fibroblastic and nonfibroblastic origin, Biochim. Biophys. Acta 222: 240.
Swann, D. A., 1969, Hyaluronic acid: Structure of the macromolecule in the connective tissue matrix, Biochem. Biophys. Res. Commun. 35: 571.
Szabo, M. M., and Roboz-Einstein, E., 1962, Acidic polysaccharides in the central nervous system, Arch. Biochem. Biophys. 98: 406.
Szirmai, J. A., 1966, Effect of steroid hormones on the glycosaminoglycans of target connective tissue, in: The Amino Sugars, Vol. 2B ( R. W. Jeanloz, and E. A. Balazs, eds.), pp. 129–154, Academic Press, New York.
Telser, A., Robinson, H. C., and Dorfman, A., 1966, The biosynthesis of chondroitin sulfate, Arch. Biochem. Biophys. 116: 458.
Terry, A. H., and Culp. L. A., 1974, Substrate-attached glycoproteins from normal and virus-transformed cells, Biochemistry 13: 414.
Thanassi, N. M., and Newcombe, D. S., 1974, Cyclic AMP and Thyroid hormone: Inhibition of epiphyseal cartilage cyclic 3’,5’-nucleotide phosphodiesterase activity by L-triiodo-thyronine, Proc. Soc. Exp. Biol. Med. 147: 710.
Toole, B. P., 1972, Hyaluronate turnover during chondrogenesis in the developing chick limb and axial skeleton, Dev. Biol. 29: 321.
Toole, B. P., 1973a, Hyaluronate and hyaluronidase in morphogenesis and differentiation, Am. Zool. 13: 1061.
Toole, B. P., 1973b, Hyaluronate inhibition of chondrogenesis: Antagonism of thyroxine, growth hormone and calcitonin, Science 180: 302.
Toole, B. P., and Gross, J., 1971, The extracellular matrix of the regenerating newt limb: Synthesis and removal of hyaluronate prior to differentiation, Dev. Biol. 25: 57.
Toole, B. P., and Lowther, D. A., 1967, Precipitation of collagen fibrils in vitro by protein
polysaccarides, Biochem. Biophys. Commun. 29:515.
Toole, B. P., and Lowther, D. A., 1968a, Dermatan sulfate-protein: Isolation from and interaction with collagen, Arch. Biochem. Biophys. 128: 567.
Toole, B. P., and Lowther, D. A., 1968b, The effect of chondroitin sulfate-protein on the formation of collagen fibrils in vitro, Biochem. J. 109: 857.
Toole, B. P., and Trelstad, R. L., 1971, Hyaluronate production and removal during corneal development in the chick, Dev. Biol. 26: 28.
Toole, B. P., Jackson, G., and Gross, J., 1972, Hyaluronate in morphogenesis: Inhibition of chondrogenesis in vitro, Proc. Natl. Acad. Sci. 69: 1384.
Trampusch, H. A., and Harrebomee, A. E., 1965, Dedifferentiation, a prerequisite of regeneration, in: Regeneration in Animals and Related Problems ( V. Kiortsis and H. A. Trampusch, eds.), pp. 341–374, North-Holland, Amsterdam.
Trelstad, R. L., 1975, Collagen fibrillogenesis in vitro and in vivo: The existence of unique aggregates and the special state of the fibril end, in: Extracellular Matrix Influences on Gene Expression ( H. C. Slavkin and R. Greulich, eds.), pp. 331–340, Academic Press, New York.
Trelstad, R. L., and Kang, A. H., 1974, Collagen heterogeneity in the avian eye: Lens, vitreous body, cornea and sclera, Exp. Eye Res. 18: 395.
Trelstad, R. L., Hayashi, K., and Toole, B. P., 1974, Epithelial collagens and glycosaminoglycans in the embryonic cornea: Macromolecular order and morphogenesis in the basement membrane, J. Cell Biol. 62: 815.
Tsiganos, C. P., Hardingham, T. E., and Muir, H., 1971, Proteoglycans of cartilage: An assessment of their structure, Biochim. Biophys. Acta 229: 529.
Vaes, G., 1967, Hyaluronidase activity in lysosomes of bone tissue, Biochem. J. 103:802. Van Harreveld, A., Crowell, J., and Malhotra, S. K., 1965, A study of extracellular space in central nervous tissue by freeze-substitution, J. Cell Biol. 25: 117.
Van Harreveld, A., Dafny, N., and Khattab, F. I., 1971, Effects of calcium on the electrical resistance and the extracellular space of cerebral cortex, Exp. Neurol. 31: 358.
Varma, R., Varma, R. S., Allen, W. S., and Wardi, A. H., 1974, On the carbohydrate—protein linkage group in vitreous humor hyaluronate, Biochim. Biophys. Acta 362: 584.
Wang, H. H., and Adey, W. R., 1969, Effects of cations and hyaluronidase on cerebral electrical impedance, Exp. Neurol. 25: 70.
Wasteson, A., Lindahl, V., and Hallen, A., 1972, Mode of degradation of the chondroitin sulphate proteoglycan in rat costal cartilage, Biochem. J. 130: 729.
Wasteson, A., Westermark, B., Lindahl, V., and Ponten, J., 1973, Aggregation of feline lymphoma cells by hyaluronic acid, Int. J. Cancer, 12: 169.
Watson, E. M., and Pierce, R. H., 1949, The mucopolysaccharide content of skin in localized (pretibial) myxedema, Am. J. Clin. Pathol. 19: 442.
Weinstein, H., Sachs, C. R., and Schubert, M., 1963, Proteinpolysaccharide in connective tissue: Inhibition of phase separation, Science 142: 1073.
Weiss, P., 1958, Cell contact, Int. Rev. Cytol. 7: 391.
Wessells, N. K., and Cohen, J. H., 1968, Effects of collagenase on developing epithelia in vitro: Lung, ureteric bud, and pancreas, Dev. Biol. 18: 294.
Wiebkin, O. W., and Muir, H., 1973, The inhibition of sulphate incorporation in isolated adult chondrocytes by hyaluronic acid, FEBS Lett. 37: 42.
Wiebkin, O. W., Hardingham, T. E., and Muir, H., 1975, Hyaluronic acid—proteoglycan interaction and the influence of hyaluronic acid on proteoglycan synthesis by chondrocytes from adult cartilage, in: Extracellular Matrix Influences on Gene Expression ( H. C. Slavkin and R. Greulich, eds.), pp. 209–224, Academic Press, New York.
Wilkinson, J. F., 1958, The extracellular polysaccharides of bacteria, Bacteriol. Rev. 22:46.
Williams, L. W., 1910, The somites of the chick, Am. J. Anat. 11: 55.
Young, I. J., and Custod, J. T., 1972, Isolation of glycosaminoglycans and variation with age in the feline brain, J. Neurochem. 19: 923.
Zugibe, F. T., 1962, The demonstration of the individual acid mucopolysaccharides in human aortas, coronary arteries and cerebral arteries. II. Identification and significance with aging, J. Histochem. Cytochem. 10: 448.
Zwilling, E., 1968, Morphogenetic phases in development, Dev. Biol. Suppl. 2: 184.
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Toole, B.P. (1976). Morphogenetic Role of Glycosaminoglycans (Acid Mucopolysaccharides) in Brain and Other Tissues. In: Barondes, S.H. (eds) Neuronal Recognition. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2205-4_10
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