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Morphogenetic Role of Glycosaminoglycans (Acid Mucopolysaccharides) in Brain and Other Tissues

  • Bryan P. Toole
Part of the Current Topics in Neurobiology book series (CTNB)

Abstract

Morphogenesis of an organ or tissue is a complex and specific series of events leading to a unique, functional organization of cellular and extracellular elements. Underlying these events are several types of cell behavior such as cell movement, recognition and adhesion, shape changes, mitosis, and death. Morphogenesis is usually accompanied by and necessary for cellular differentiation, in which the component cells undergo a series of distinctive metabolic and cytological changes that result in the synthesis or secretion of characteristic and functional cell products. Although morphogenesis and differentiation are not exact or discrete terms (they both involve metabolic, cytological, and behavioral changes), it is the behavioral aspects that are emphasized when morphogenesis is spoken of and the metabolic and cytological changes that are emphasized when differentiation is spoken of.

Keywords

Hyaluronic Acid Heparan Sulfate Chick Embryo Keratan Sulfate Acid Mucopolysaccharide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Bryan P. Toole
    • 1
  1. 1.Developmental Biology Laboratory, Departments of Medicine and Biological ChemistryHarvard Medical School at Massachusetts General HospitalBostonUSA

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