The processing of electrical signals by the brain has long held a particular fascination for students and researchers. When DuBois Reymond made the first successful laboratory measurements of the nerve impulse in the mid-19th century, he wrote: “If I do not greatly deceive myself, I have succeeded in realizing in full actuality… the hundred years’ dream of physicists and physiologists, to wit, the identification of the nervous principle with electricity.” About half a century later Sherrington, in a classic work summarizing his research on the integration of spinal reflex activity, characterized the nervous system as “… an enchanted loom where millions of flashing shuttles weave a dissolving pattern, always a meaningful though never an abiding one.”
KeywordsPyramidal Cell Spike Train Single Neuron Synaptic Contact Giant Axon
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