Neurobiological Mechanisms of Adaptation in Relation to Models of Psychobiological Development
Once defined by anatomical features or electrical activity, neural systems in the brain can now be discriminated by neurochemical techniques. The neurons in each system synthesize and release or store specific chemicals to excite subsequent cells in their respective pathways. For several years my colleagues and I (and others in other laboratories) have been studying a number of macromolecular adaptive changes affecting the function of adrenergic and serotonergic transmission in the brain. In the former, norepinephrine is thought to be related to states of arousal, attention, and perhaps to mood; in the latter, serotonin has been implicated in involuntary vascular functions, emotional memory, and moods of sexuality and rage.
KeywordsTyrosine Hydroxylase Nerve Ending Tryptophan Hydroxylase Neurobiological Mechanism Tyrosine Hydroxylase Activity
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- Eiduson, S. The developmental-biochemical approach in man. In A. J. Mandell and M. P. Mandell (Eds.), Psychochemical research in man. New York: Academic Press, 1969. Pp. 147–159.Google Scholar
- Knapp, S., and Mandell, A. J. Some drug effects on the functions of the two physical forms of tryptophan-5-hydroxylase: influence on hydroxylation and uptake of substrate. In J. Barchus and E. Usdin (Eds.), Serotonin and Behavior. New York: Academic Press, 1973, Pp. 61–71. (b).Google Scholar
- Spitz, Rene. Hospitalism. An inquiry into the genesis of psychiatric conditions in early childhood. In A. Freud et al. (Eds.), The psychoanalytic study of the child. New York: International Universities Press, 1945, Pp. 53–74.Google Scholar
- Spitz, Rene. Anaclitic depression. In A. Freud et al. (Eds.), The psychoanalytic study of the child. New York: International Universities Press, 1946. Pp. 313–342.Google Scholar
- Sullivan, J. L., Segal, D. S., Kuczenski, R. T., and Mandell, A. J. Propranolol-induced rapid activation of rat striatal tyrosine hydroxylase concomitant with behavioral depression. Biological Psychiatry, 1912, 4, 193–203.Google Scholar