Animal Models of Violence and Hyperkinesis

Interaction of Psychopharmacologic and Psychosocial Therapy in Behavior Modification
  • Samuel A. Corson
  • E. O’Leary Corson
  • L. Eugene Arnold
  • Walter Knopp


In reviewing the dramatic discrepancy between the many favorable clinical reports on meprobamate and a number of negative laboratory studies on this drug, Gerard (1957), in his usual elegant and succinct manner, summarized the situation as follows: “On the one hand, laboratory studies indicate that meprobamate is quite inert; on the other hand, a great number of takers seem to experience some benefit, and clinical reports included in these pages—many seemingly well controlled and convincing enough as reported—indicate a definite action. From this, one must conclude either that the experimenters have not yet found the right thing to test—which would not be surprising, since we are dealing with agents active on the nuances of complex human behavior for which it is difficult to find electrical or chemical indicators, either in the laboratory or in the patient—or else the clinical impressions are wrong. ... I doubt that the latter is the case, especially because of the genuine awareness of the problem of controls that exists today among the better clinicians and laboratory workers handling these problems.”


Violent Behavior Pavlovian Conditioning Contingent Negative Variation Soft Neurological Sign Calming Effect 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Samuel A. Corson
    • 1
  • E. O’Leary Corson
    • 1
  • L. Eugene Arnold
    • 1
  • Walter Knopp
    • 1
  1. 1.Laboratory of Cerebrovisceral Physiology, Division of Behavioral and Neurobiological Sciences, Department of Psychiatry, College of MedicineOhio State UniversityColumbusUSA

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