Animal Models for Human Psychopathology

Observations from the Vantage Point of Clinical Psychopharmacology
  • Dennis L. Murphy


In our clinical studies of depressed and manic individuals, we regularly make use of data from animal studies in planning our research and in evaluating our results. The data we use most come from studies of the neurochemical effects of drugs, and, to a lesser extent, data on the effects of drugs on the behavior of normal animals. In contrast, we rarely use biochemical or behavioral data derived from studies of abnormal animals—either strains exhibiting altered behavior or neurochemistry, or animals with induced “psychopathology,” because very little such information is available. One rapidly growing area of investigation, however, which was discussed in papers by Drs. Domino and Irwin, is the utilization of drugs which produce states of abnormal behavior in animals and man. Some of the more prominent examples of these pharmacologic agents are listed in Table I.


Biogenic Amine Psychoactive Drug Antidepressant Effect Altered Behavior Separation Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Dennis L. Murphy
    • 1
  1. 1.Laboratory of Clinical ScienceNational Institute of Mental HealthBethesdaUSA

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