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Drug Effects on Foot-Shock-Induced Agitation in Mice

  • Samuel Irwin
  • Roberta G. Kinohi
  • Elaine M. Carlson

Abstract

Foot-shock-induced fighting was first described for rats by O’Kelly and Steckle (1939) and later used for drug studies with mice by Tedeschi, Tedeschi, Mucha, Cook, Mattis, and Fellows (1959). Our interest in this procedure arose from the observation by Valzelli (1967) that foot-shock-induced fighting was more sensitive to drug effects and easier to carry out than other procedures used for this purpose (e.g., isolation or drug-induced fighting). Also, the procedure offered means for measuring drug effects on other distress components of behavior exhibited by animals in response to foot-shock stimulation (such as vocalization, running, and leaping).

Keywords

Drug Effect Chronic Administration Narcotic Analgesic Spontaneous Locomotor Activity Chronic Dose 
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References

  1. Irwin, S. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia (Berl.), 1968, 13, 222–257.CrossRefGoogle Scholar
  2. Irwin, S. Drug effects on distress-evoked behavior in mice: Methodology and drug class comparisons. Psychopharmacologia (Berl.), 1971, 20, 172–185.Google Scholar
  3. O’Kelly, L. W., & Steckle, L. C. A note on long enduring emotional responses in the rat. J. Phychol, 1939, 8, 125–131.CrossRefGoogle Scholar
  4. Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A., & Fellows, E. J. Effects of various centrally acting drugs on fighting behavior of mice. J. Pharmacol. Exp. Ther., 1959, 125, 28–33.PubMedGoogle Scholar
  5. Valzelli, L. Drugs and aggressiveness. In Advances in Pharmacology 5, New York: Academic Press, pp. 79–108.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Samuel Irwin
    • 1
  • Roberta G. Kinohi
    • 1
  • Elaine M. Carlson
    • 1
  1. 1.Department of PsychiatryUniversity of Oregon Medical SchoolPortlandUSA

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