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Information Transfer in Ageing: An Allosteric Model of Hormonal Regulation

  • Julia G. Vassileva-Popova
  • T. K. Yanev

Abstract

The aim of this study is to investigate the character of the information transfer in time between a central regulatory protein i.e. a protein hormone (PH) and target receptors (TR) recognizing this signal. In search for a possible solution of this question the following limitations were selected:
  • The experimental analysis includes only the first steps of recognition introduced as complex formation between PH and TR (adenohypophysial PH and gonadal TR).

  • Because of not yet enough evidence for the age alteration of the hormonal structure during the ontogenesis the focus of this study will be on the TR ageing transformation; especially the changes of the TR ability for recognition of the central signal (CS) incorporated in the PH.

  • The investigation of the ageing changes of the message transfer between the PH and the TR became of interest for us because of new data available from the advance in ageing research and the related topics.

Keywords

Interstitial Cell Stimulate Hormone Free Amino Acid Naukova Dumka Information Transfer Hormonal Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Symbols used

(PH)

Protein hormone

(ICSH)

Interstitial cell stimulating hormone

(CS)

Central signal

(SS)

Sex Steroid

(TR)

Target receptor

(A)

Active state of TR

(P)

Semipassive state of TR

(E)

Enzyme

(S)

Substrate

(FAA)

Free amino acids

(CNS)

Central nervous system

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Julia G. Vassileva-Popova
    • 1
  • T. K. Yanev
    • 1
  1. 1.Central Laboratory of BiophysicsBulgarian Academy of SciencesSofiaBulgaria

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