Adenohypophysis and the Male Gonadal Axis Following Partial Body δ - Irradiation

  • G. S. Gupta


Of all cellular elements of vertebrate testis, spermatogonia are by far the most sensitive to ionising radiation. Sertoli and interstitial cells on the other hand are relatively radio-resistant (Rugh, 1960; Ellis, 1970). So much so that the interstitial tissue gets hypertrophied (McEnery and Nelson, 1953; Lindsey et al, 1969; Gupta and Bawa, 1974a, 1975a) and hyperplasia of interstitium, at times is converted into neoplasia (Lindsey et al, 1969). The possible explanation for the origin of the neoplasia is related to the endocrine imbalance and to the altered testis pituitary axis following localised irradiation (Lindsey et al, 1969; Ellis, 1970; Gupta and Bawa, 1974b; 1974c). However, evidences of the altered cytomorphology of the pituitary after irradiation of testis are lacking (Lindsey et al, 1970). The present report describes the molecular changes associated with hyperplastic rat testis interstitium subjected to localized δ-irradiation and their relations with altered testis-pituitary axis.


Partial Body Interstitial Tissue Sublethal Dose Testicular Tubule Alcohol Soluble Fraction 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • G. S. Gupta
    • 1
  1. 1.Department of BiophysicsPanjab UniversityChandigarhIndia

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