Hypothalamic - Pituitary Function and Ageing

  • M. R. P. Hall


Although there is nothing new about ageing it is only in comparatively recent times that large numbers of people have survived to reach old age. Havighurst, at a meeting on Leisure and the 3rd. Age held in Dubrovnik in May 1972 estimated that two- thirds of those who have reached the age of 65 in the last 2,000 years are alive today. This gives some idea of the current explosion of old age. In the United Kingdom about 15% of the population are over the age of 65 years. Most European countries have similar figures while other developed countries such as the United States, Australia and New Zealand have aged populations which approach 10% of the total population. Even in the underdeveloped countries the population is beginning to show signs of ageing and many of these have more than 5% over the age of 65 years.


Human Growth Hormone Plasma Cortisol Level Adrenocortical Function Round Table Discussion Metyrapone Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Havighurst R. “Life Style and Leisure Patterns” pp 35–48, Proc. 3rd Int. Course of Social Gerontology, 1972, Leisure and the 3rd Age, Int. Center of Social Gerontology.Google Scholar
  2. Weissman A. Essays upon Heredity and Kindred Biological Problems. Oxford University Press, London and New York 1891Google Scholar
  3. Smith M.J. and Hall M.R.P. Carbohydrate Tolerance in the Very Aged, Diabetologia 9, 387–390, 1973PubMedCrossRefGoogle Scholar
  4. Gusseck D.J. In “Endocrine Mechanisms and Ageing” pp 105–66 Advances in Gerontological Research, ed. B.L. Strehler, Academic Press, New York and London 1972Google Scholar
  5. Everitt A.V. The hypothalamic-pituitary control of Aging and Age-related Pathology, Exp. Geront. 8, 265–277, 1973CrossRefGoogle Scholar
  6. Smith P.E. Anat. Rec. 32, 221, 1926Google Scholar
  7. Bellamy D. Long term action of prednisolone phosphate on a strain of short lived mice1 Exp. Gerontol. 4, 327–334, 1968CrossRefGoogle Scholar
  8. Gelfont S. and Smith J.G. Ageing: Noncycling cells—an explanation, Science, 178, 357–361, 1972CrossRefGoogle Scholar
  9. Allison A.C. The role of Lysosomes in Pathology1 Proc. Roy. Soc. Med. 59, 867–868, 1966PubMedGoogle Scholar
  10. Fabris N., Lymphocytes, Hormones and Ageing, Nature, 240, 557–559, 1972PubMedCrossRefGoogle Scholar
  11. Hall, David A., Reed F.B., Nuki G., and Vince J.D. Effects of age and corticosteroid therapy on skin collagen in human subjects, Communication to the British Society for Research on Ageing, October 1973.Google Scholar
  12. Hess, G.D. and Riegle G.D. Adrenocortical Responsiveness to Stress and ACTH in Aging Rats, J. Geront., 25, 354–358, 1970PubMedGoogle Scholar
  13. Breznock, E.M. and McQueen R.D. Adrenocortical Function during Aging in the Dog, Amer. J. Vet. Res. 31, 1269–1272, 1970.Google Scholar
  14. Riegle G.D. and Nellor J.E., Changes in adrenocortical function during aging in Cattle, J. Geront. 22, 83–87, 1967.PubMedGoogle Scholar
  15. Riegle G.D., Przekop F. and Nellor J.E., Changes in Adreno-cortical Responsiveness to ACTH. infusion in Aging Goats, J. Geront. 23, 522–528, 1969Google Scholar
  16. Grad B. and Khalid R. Circulating Corticosterone levels in Young and Old, Male and Female C57B1/6J Mice. J. Geront. 23, 522–528, 1969Google Scholar
  17. Jensen H.K. and Blichert-Toft M. Pituitary Adrenal Function in Old Age evaluated by the intravenous metyrapone test, Acta. Endocrin, 64, 431–438, 1970.Google Scholar
  18. Laron Z., Doron M. and Amikan B. Serum Growth Hormone in Old Age. J. Israel. Med. Assoc. 73, 375–378, 1967.Google Scholar
  19. Friedman, M., Green M.F. and Sharland D.E. Assessment of Hypothalamic-Pituitary-Adrenal Function in the Geriatric Age Group, J. Geront. 24, 292–297, 1969PubMedGoogle Scholar
  20. Cartlidge N.E.F., Black M.M., Hall M.R.P. and Hall R. Pituitary Function in the Elderly, Geront. clin. 12, 65–70, 1970.PubMedCrossRefGoogle Scholar
  21. Laron Z., Doron M. and Amikan B. Plasma Growth Hormone in men and women over 70 years of age. In Medicine and Sport IV p.126–131 Petah Tigra—Karger (Basel) 1970.Google Scholar
  22. West C.D., Brown H., Simons E.L., Carter D.B., Kumagai L.F. and Englert E. Jr., Adrenocortical Function and Cortisol Metabolism in Old Age, J. Clin. Endocrinol & Metab. 21, 1197–1207, 1961CrossRefGoogle Scholar
  23. Romanoff, Louise P., Morris, Carol W., Welch Patricia, Rodriguez Rosa M. and Pincus G. The metabolism of Cortisol-4-C in excretion of tetrahydrocortisol allotetrahydrocortisol, tetrahydrocortisone and cortolone (20a and 203) J. Clin. Endocrinol and Metab. 21, 1413–1425, 1961.CrossRefGoogle Scholar
  24. Carroll B.J., Pearson, Margaret J. and Martin, F.I.R. Evaluation of three acute tests of Hypothalamic-Pituitary- Adrenal Function, Metabolism, 18, 476–483, 1969PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • M. R. P. Hall
    • 1
  1. 1.University of SouthamptonSouthamptonEngland

Personalised recommendations