Oxytocin Effect on the Depolarized Rat Uterus: A Mathematical Approach Using System Identification

  • Oskar Wanner
  • Vladimir Pliška


It is becoming increasingly recognized that “classical” pharmacological receptor theory, operating with relatively few fundamental concept such as receptor binding, stimulus generation, and stimulus-effect coupling is not fully adequate in describing the behaviour of actual experimental systems /1/. Nor have the recent advances in molecular endocrinology, however important in themselves, contributed to this particular problem since they have mainly been concerned with simplified biological systems at the cellular or subcellular level.


Transfer Function Hormone Concentration Organ Bath Receptor Compartment Parallel Branch 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Oskar Wanner
    • 1
  • Vladimir Pliška
    • 2
  1. 1.Institute of Measurement and ControlSwiss Federal Institute of TechnologyZürichSwitzerland
  2. 2.Institute of Molecular Biology and BiophysicsSwiss Federal Institute of TechnologyZürichSwitzerland

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