Testicular Feminization Syndrome: A Model of Chemical Information Non-Transfer

  • Robert C. Northcutt
  • David O. Toft


In 1950, Lawson Wilkins 1 of Johns Hopkins Hospital reported a patient which he described as a “hairless women with testes” who failed to develop any signs of virilization on prolonged administration of large doses of testosterone and methyltestosterone. From this observation, he drew the inference that this syndrome might result from a “genetic end-organ unresponsiveness” to the action of testosterone and not to a deficiency of testosterone production. In 1953, Morris 2 is credited with the definitive clinical description of the testicular feminization syndrome. Since that time, many other investigators have contributed to our understanding of the clinical and pathophysiologic features of the disorder. The clinical features of the syndrome of testicular feminization are summarized in Table 1.


Inguinal Hernia Accessory Structure Pubic Hair Bilateral Inguinal Hernia Cytosol Receptor 
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  1. 1).
    Wilkins, L.M.: The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence. Charles C. Thomas, Springfield, III. 1950, p. 271.Google Scholar
  2. 2).
    Morris, J.M.: The Syndrome of Testicular Feminization in Male Pseudohermaphrodites. Am. J. Obstet. and Gynec. 65: 1192, 1953.Google Scholar
  3. 3.
    Rosenfield, R. L., Lawrence, A. M., Liao, Landau, R. L.: Androgens and Androgen Responsiveness in the Feminizing Testis Syndrome. Comparison of Complete and Incoplete Forms. J. Clin. Endocrinol. Metab. 32: 625, 1971PubMedCrossRefGoogle Scholar
  4. 4).
    Southren, A.L., Sharma, D.C., Ross,H., Sherman, D., Gordon, G.: Plasma Concentration and Biosynthesis of Testosterone in the Syndrome of Feminizing Testes. Bull. N. Y. Acad. Med. 40: 86, 1964.Google Scholar
  5. 5).
    Judd, H. L., Hamilton, C. F., Barlow, J. J., Yen, S. S. C., Kliman, B.: Androgen and Gonadotropin Dynamics in Testicular Feminization Syndrome. J. Clin. Endocrol. and Metab. 34: 229, 1972.CrossRefGoogle Scholar
  6. 6).
    Morris, J.M., Mahesh, V. B.: Further Observations on the Syndrome, Testicular Feminization. Am. J. Obstet. and Gynec. 87: 731, 1963.Google Scholar
  7. 7).
    Bruchovsky, N., Wilson,J.D.: The Conversion of Testosterone to 5 -Androstan-17 -ol-3-one by Rat Prostate in Vivo and in Vitro. J. Biol. Chem. 243: 2012, 1968.PubMedGoogle Scholar
  8. 8).
    Northcutt, R. C., Island, D. P., Liddle, G. W.: An Explanation for the Target Organ Unresponsiveness to Testosterone in the Testicular Feminization Syndrome. J. Clin. Endocrinol. and Metab. 29: 422, 1969.CrossRefGoogle Scholar
  9. 9).
    Schindler, A. E., Keller, E., Friedrich,E., Jaeger-White-giver, E.R.: In Vivo and in Vitro Studies in Patients with Testicular Feminization. J. Steroid Biochem. 5: 371, 1974. (Abstract 317)CrossRefGoogle Scholar
  10. 10).
    Northcutt, R.C., Kaminsky, N. I.: Unpublished Observations.Google Scholar
  11. 11).
    Strickland, A. L., French,F.S.,: Absence of Response to Dihydrotestosterone in the Syndrome of Testicular Feminization. J. Clin. Endocrinol. and Metab. 29: 1284, 1969.CrossRefGoogle Scholar
  12. 12).
    Korenman, S. G.: Relation between Estrogen Inhibitory Activity and Binding to Cytosol of Rabbit and Human Uterus. Endocrinology. 87: 1119, 1970.CrossRefGoogle Scholar
  13. 13).
    Bardin,C.W., Bullock,L.P., Sherins,R.J., Mowszowicz, Blackburn, W. R.: Androgen Metabolism and Mechanism of Action in Male Pseudohermaphroditism: A study of Testicular Feminization. Ree.Progr. Hormone Res. 2 9: 65, 1973.Google Scholar
  14. 14.
    McLean, W.S., Smith, A.A., Hansson, V.,Nayfeh, S.N., French, F.S.: Androgen Receptor in Seminiferous Tubules of Immature Rat Testes: Absence of the Receptor in the Androgen Insensitive Stanley-Gumbreck (Tfm) Rat. Program. 56th Annual Meeting Endocrine Society, 1974, p. A-198, Abstract 286.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Robert C. Northcutt
    • 1
    • 2
  • David O. Toft
    • 1
    • 2
  1. 1.Division of EndocrinologyMayo ClinicRochesterUSA
  2. 2.Department of Molecular MedicineMayo ClinicRochesterUSA

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