Testicular Feminization Syndrome: A Model of Chemical Information Non-Transfer

  • Robert C. Northcutt
  • David O. Toft


In 1950, Lawson Wilkins 1 of Johns Hopkins Hospital reported a patient which he described as a “hairless women with testes” who failed to develop any signs of virilization on prolonged administration of large doses of testosterone and methyltestosterone. From this observation, he drew the inference that this syndrome might result from a “genetic end-organ unresponsiveness” to the action of testosterone and not to a deficiency of testosterone production. In 1953, Morris 2 is credited with the definitive clinical description of the testicular feminization syndrome. Since that time, many other investigators have contributed to our understanding of the clinical and pathophysiologic features of the disorder. The clinical features of the syndrome of testicular feminization are summarized in Table 1.


Inguinal Hernia Accessory Structure Pubic Hair Bilateral Inguinal Hernia Cytosol Receptor 


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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Robert C. Northcutt
    • 1
    • 2
  • David O. Toft
    • 1
    • 2
  1. 1.Division of EndocrinologyMayo ClinicRochesterUSA
  2. 2.Department of Molecular MedicineMayo ClinicRochesterUSA

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