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Receptor Transformation — A Key Step in Estrogen Action

  • E. V. Jensen
  • S. Mohla
  • T. A. Gorell
  • E. R. DeSombre

Abstract

Experiments from many laboratories (1,2) have established that, for all classes of steroid hormones, the hormone-receptor complex found in the nuclei of target cells is derived from an initially formed extranuclear complex, as first proposed for estrogens in uterine tissue (3,4). Evidence is accumulating that the steroid-induced translocation of the hormone-receptor complex to the nucleus is accompanied by a hormone-mediated alteration of the receptor protein, a process that has been called receptor transformation (5–7) or activation (8, 9). This paper summarizes some observations concerning transformation of estrophilin, the receptor protein for estrogens, and describes recent achievements in the purification of the transformed estradiol-receptor complex of calf uterus.

Keywords

Estrogen Action Uterine Tissue Nuclear Complex Neighbor Frequency Nuclear Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • E. V. Jensen
    • 1
    • 2
  • S. Mohla
    • 1
    • 2
  • T. A. Gorell
    • 1
    • 2
  • E. R. DeSombre
    • 1
    • 2
  1. 1.Ben May LaboratoryUniversity of ChicagoChicagoUSA
  2. 2.Department of BiophysicsUniversity of ChicagoChicagoUSA

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