Sex-Dependent Prolactin Pattern during Development

  • Julia Vassileva-Popova
  • J. R. Tata


Despite its name which suggests a very specific role in the control of lactation, the hormone prolactin is now known to regulate numerous physiological functions in a wide variety of vertebrate species. Although suggestions have already been made that prolactin exerts different effects on the male reproductive tract f but it is not yet clear as to what physiological role this pituitary hormone may play in the male mammal. It seemed to us that before a precise hormonal function could be ascribed it is essential to establish quantitatively the prolactin /Pr/ level in the pituitaty and blood of male animals. Furthermore, from a consideration of the possibility of an important role for Pr during sexual maturation we decided that it would be more useful to determine Pr levels in the developing male and compare the data with the Pr level in developing females. In this paper we describe our initial findings on the comparison of circulating and hypophyseal levels of prolactin in developing male and female rats. It will be shown that Pr is present in high amounts in the neonatal male pituitary and that substantial levels of circulating hormone are maintained during the first weeks of development of the male. The pattern of changes in the hypophyseal and circulating prolactin in the male did not correspond to that in the female.


Blood Serum Pituitary Gland Pituitary Tissue Male Reproductive Tract Separate Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hunter, W.M.,and Greenwood, F.C., Nature (London), 194, 495 (1962).CrossRefGoogle Scholar
  2. 2.
    Edwardson, J.A., and Vassileva-Popova, J., Proc. Second Int. Symp. Varna, Sept.13–16, 1972, Bulg. Acad. Sci. Press, Sofia, 1973.Google Scholar
  3. 3.
    Wakabayashy, I., Arimwa, A., Fed.Proc., 30, (1971).Google Scholar
  4. Amenomori, Y., Chen, C.L., Meites, J., Endocrinology, 86, 506, (1970).PubMedCrossRefGoogle Scholar
  5. 5.
    Kwa, H.G., Verhoptad, F., J. Endocrinol. 39, 4551, (1967).CrossRefGoogle Scholar
  6. 6.
    Mallampati, R.S., Srivastava, L.S., Fed. Proc., 30, 474, (1971).Google Scholar
  7. 7.
    Neill, J.D., Reichart, L.E., Endocrinology, 88, 548, (1971).PubMedCrossRefGoogle Scholar
  8. 8.
    Moger, H.,and Geschwind, I.I., P.SoE.B.M., 141, 1017, (1972).Google Scholar
  9. 9.
    Bartke, A., J.Endocrinol., 49, 311, (1971).PubMedCrossRefGoogle Scholar
  10. 10.
    Hafiez, A.A., Philpott, J.E., and Bartke, A., docrinol., 50, 619, (1971).Google Scholar
  11. 11.
    Hafiez, A.A., Lloyd, C.W., and Bartke, A., J. crinol., 52, 327 (1971).Google Scholar
  12. 12.
    Chase, M.D., Geschwind, I.I., and Bern, H.A., Soc. Exp. Biol. Med., 84, 680, (1957).Google Scholar
  13. 13.
    Von Berswordt-Warlrabe, R., Steinbeck, H., Hahn, J.D., and Elger, W., Experientia, 25, 533, (1969).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Julia Vassileva-Popova
    • 1
  • J. R. Tata
    • 2
  1. 1.Central Laboratory of BiophisicsBulgarian Academy of ScienceSofiaBulgaria
  2. 2.National Institute for Medical ResearchLondonGreat Britain

Personalised recommendations