Effect of PGF-2alfa on the Synthesis of Placental Proteins and HPL
The synthesis and secretion of human placental lactogen (HPL) is thought to be autonomous (Friesen., 196 8). An increased number of evidence has been accumulated indicating that prostaglandins are involved in the regulation of HPL biosynthesis and secretion. According to Ylikorkala and Pennanen (1973) PGF-2alfa administered by intrauterine routes appeared to have a direct effect on the placental synthesis and/or release of HPL in early pregnancies. Karim and Hillier (1970) found high concentrations of PGF-alfa in human amniotic fluid in spontaneous abortions. On the basis of this evidence it is not surprising that the plasma level of HPL is lower than normal in threatened abortion (Niven et.al.1972) even if the outcome of pregnancy is successful (Ylikorkala et.al. 1973).
KeywordsLegal Abortion Human Amniotic Fluid Abortion Induction Human Placental Lacto Term Human Placenta
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