On the Role of the Conformation Changes at the Active Site for Allosteric Interactions
In the existing theoretical works on the allosteric interactions in proteins only the subunit interactions are considered without taking into account the conformation changes in the active sites themselves. The present paper is an effort to take into consideration the role of the fine conformation changes in the allosteric interactions at the active sites. The respective correction factors to the rate constants of ligand binding in the equation of saturation (Eq. of Adair) have been found. The mathematical formalism for the fluctuation equilibrium between, a number of conformation states of the active site with different ligand affinities has been obtained.
KeywordsFree Energy Conformation Change Activation Free Energy Subunit Interaction Conformation State
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- 3.Adair G.S., J. Biol. Chem. 6 3, (1925) 529Google Scholar