Trauma pp 71-84 | Cite as

Effects of Ionizing Radiation on Hemopoiesis

  • Eugene P. Cronkite


Radiation affects most remarkably those tissues of the body that are in a steady state of renewal, such as hemopoietic tissues, gastro-intestinal tract, skin and testes. Radiation effects may be subtle and not expressed for many years, or they may be acute coming on promptly and producing severe symptomatology related to the central nervous system, the gastrointestinal tract or the hematopoietic system. All radiation effects have distinct dose-effect relationships which are reasonably well established. The symptomatology will also vary, depending upon whether the entire body is exposed or whether only a portion of the body has been exposed. Dose rate, the type of radiation, the distribution of absorbed dose within the body, fractionation and oxygen tension of tissues are all factors that influence the intensity and the type of radiation effect that may be observed at various time intervals after the exposure.


Dose Rate Ionize Radiation Radiation Injury Cosmic Radiation Relative Biological Effectiveness 
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  1. 1.
    Russell, W.L., The effect of radiation dose rate and fractionation on mutation in mice. In: Repair from Genetic Radiation Damage. Ed. by F. Sobels, Pergamon Press (Oxford) 1963, pp. 205–217, 231-235.Google Scholar
  2. 2.
    Libby, W.F., Proc. National Acad. Sci. 45, 959–976, 1959.CrossRefGoogle Scholar
  3. 3.
    Cronkite, E.P., Radiation injury in man. Chap. V in The Biological Basis of Radiation Therapy. Ed. by E.E. Schwartz, J.B. Lippincott Co., Philadelphia and Toronto, 1966.Google Scholar
  4. 4.
    Lea, D.E., Action of Radiation on Living Cells. MacMillan Co., New York, 1947.Google Scholar
  5. 5.
    Bond, V.P., T.M. Fliedner, and J.O. Archambeau, Mammalian Radiation Lethality. Academic Press, New York and London, 1965.Google Scholar
  6. 6.
    Till, J.E. and E.A. McCullough, A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Rad. Res. 14, 213–222, 1961.CrossRefGoogle Scholar
  7. 7.
    Hempelmann, L.H., H. Lisco, and J.C. Hoffman, The acute radiation syndrome: a study of nine cases and a review of the problem. Ann. Int. Med. 36, 279–510, 1952.Google Scholar
  8. 8.
    Shipman, T.L., A radiation fatality resulting from massive overexposure to neutrons and gamma rays in Diagnosis and Treatment of Radiation Injury. pp. 113–133, WHO, Geneva, 1961.Google Scholar
  9. 9.
    Howland, J.W., M. Ingram and H. Mermagen, The Lockport Incident: Accidental partial body exposure of humans to large doses of x irradiation in Diagnosis and Treatment of Radiation Injury. pp.11–26, WHO, Geneva, 1961.Google Scholar
  10. 10.
    Cronkite, E.P., V.P. Bond and C.L. Dunham, Some Effects of Ionizing Radiation on Human Beings. U.S. Atomic Energy Com. TID 5358, Supt. of Documents, U.S. Gov’t Printing Office, Wash., D. C., 1956.Google Scholar
  11. 11.
    Ionizing Radiation: Levels and Effects. A report of the U.N. Scientific Committee on the Effects of Atomic Radiation to the General Assembly. Vol II, 1972, New York and Geneva.Google Scholar
  12. 12.
    The Effects on Populations of Exposure to Low Levels of Ionizing Radiation. Report of the Advisory Committee on the Biological Effects of Ionizing Radiations. (BEIR report), Division of Medical Sciences, National Acad. of Sci., NRC, Wash., D. C., 1972.Google Scholar
  13. 13.
    Bond, V.P. Radiation effects data and their interpretation. Presented: American Bar Association, National Institute/ Environmental Litigation, Dallas, Texas, 12–14 April 1973.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Eugene P. Cronkite
    • 1
  1. 1.Medical Research CenterBrookhaven National LaboratoryUSA

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