Trauma pp 171-190 | Cite as

Physiologic Effects of Endotoxemia

  • Hugh C. Gilbert
  • Gerald S. Moss


Since the recognition of the specific shock syndrome associated with gram negative septicemia, the pathophysiology of endotoxemia has received world-wide attention. Numerous investigators have contributed to the understanding of the pathophysiologic interplay felt to be a part of the endotoxic syndrome. This effort has spanned the spectrum of the life sciences and has resulted in a wealth of information focusing on various possible pathophysiologic mechanisms.


Disseminate Intravascular Coagulation Renal Blood Flow Myocardial Contractility Contractile Element Endotoxin Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Alican, F. M., Dolton, L., and Hardy, J. D.: Experimental Endotoxin Shock: Circulatory Changes with emphasis upon cardiac function. Amer. J. Surg., 193:702, 1962.CrossRefGoogle Scholar
  2. 2.
    Beeson, P. B.: Effect of reticulo-endothelial blockade on immunity to the Schwartzman Phenomenon. Proc. Soc. Exp. Biol. Med., 64:146, 1947.Google Scholar
  3. 3.
    Bennett, I. L.: Approaches to the Mechanism of Endotoxin Action. (Eds.) Landy, M., and Braum, W. In: Bacterial Endotoxins. Quinn and Boden Company, Inc., Rahway, New Jersey, p. XIV, 1964.Google Scholar
  4. 4.
    Bohr, C., Hasselbalch, K., and Krogh, A.: Ueber einem in biologischer Beziehung wichtigen Einfluss, den die Kohlensespannung des Blutes auf dessen Sauerstoffbindung übt. Skand. Archiv. F. Physiol., XVI:401, 1904.Google Scholar
  5. 5.
    Braunwald, E.: Editorial: On the Difference Between the Heart’s Output and its Contractile State. Circulation, 43:171, 1971.Google Scholar
  6. 6.
    Cavanagh, R., Papineni, S. R., Sutton, D. M. C., Bhagat, C., and Bachman, B. D.: Pathophysiology of endotoxin shock in the primate. Amer. J. Obstet. Gynecol., 108:705, 1970.Google Scholar
  7. 7.
    Coalson, J. J., Hinshaw, L. B., and Guenter, C. A.: The pulmonary ultrastructure in septic shock. Exp. Mol. Pathol., 12:84, 1970.CrossRefGoogle Scholar
  8. 8.
    Davis, R. B., Meeker, W. R., and Bailey, W. L.: Serotonin release by bacterial endotoxin. Proc. Soc. Exp. Biol. Med., 108:774, 1961.Google Scholar
  9. 9.
    Fletcher, J. R., Hirsh, E. F., and Lucas, S.: Renal function after sepsis in combat casualties. Surg. Gynec. Obstet., 133:237, 1971.Google Scholar
  10. 10.
    Guenter, C. A., Fiorica, V., and Hinshaw, L. B.: Cardiorespiratory and metabolic responses to live E. coli endotoxin in the monkey. J. Appl. Physiol., 26:789, 1967.Google Scholar
  11. 11.
    Hardaway, R. M.: Intravascular Coagulation in Shock. (Eds.) Malinin, T. I., Zeppa, R., Gollan, F., and Callahan, A. B. In: Reversibility of Cellular Injury Due to Inadequate Perfusion. C. C. Thomas Company, Springfield, Illinois, pp. 373–386, 1972.Google Scholar
  12. 12.
    Hardaway, R. M., Hiesni, E. A., Guber, E. F., Noyes, H. E., and Burns, J. W.: Endotoxin Shock: A manifestation of intravascular coagulation. Ann. Surg., 154:791, 1961.CrossRefGoogle Scholar
  13. 13.
    Hermreck, A. S., and Thal, A. P.: Mechanisms for the high circulatory requirements in sepsis and septic shock. Ann. Surg., 170:677, 1969.CrossRefGoogle Scholar
  14. 14.
    Herring, W. B., Herion, J. C., Walker, R. I., and Palmer, J. G.: Distribution and clearance of circulating endotoxin. J. Clin. Invest., 42:79, 1963.CrossRefGoogle Scholar
  15. 15.
    Hill, A. V.: Heat of shortening and dynamic constants of muscle. Proc. Royal Soc-London, S. B., 126:135, 1938.Google Scholar
  16. 16.
    Hinshaw, L. B., Archer, L. T., Greenfield L. J., and Guenter, C. A.: Effects of endotoxemia on myocardial hemodynamics, performance, and metabolism. Amer. J. Physiol.,221:504, 1971.Google Scholar
  17. 17.
    Hinshaw, L. B., Greenfield, L. S., Owen, S. E., Black, M. R., and Guenter, C. A.: Precipitation of cardiac failure in endotoxin shock. Surg. Gynec. Obstet., 135:41, 1972.Google Scholar
  18. 18.
    Hinshaw, L. B., Spink, W. W., Vich, J. A., Mallet, E. and Finstad, J.: The effect of endotoxin on kidney function and renal hemodynamics in the dog. Amer. J. Physiol., 201:144, 1961.Google Scholar
  19. 19.
    Hinshaw, L. B., Bradley, G. M., and Carlson, C. H.: Effect of endotoxemia on renal function in the dog. Amer. J. Physiol., 196:1127, 1959.Google Scholar
  20. 20.
    Holper, K., Trejo, R. A., Brettschneider, L., and Di Inzio, N. R.: Enhancement of endotoxin shock in the lead-sensitized sub-human primate. Surg. Gynec. Obstet., 136:593, 1972.Google Scholar
  21. 21.
    Horwitz, D. L., Moquin, R. B., and Herman, C. M.: Coagulation changes of septic shock in the sub-human primate and their relationship to demodynamic change. Ann. Surg., 175:417, 1972.CrossRefGoogle Scholar
  22. 22.
    Kim, Y. B., and Watson, D. W.: Modification of host responses to bacterial endotoxin. II. Passive transfer to immunity to bacterial endotoxin with factions containing 195 antibodies. J. Exp. Med., 121:751, 1965.Google Scholar
  23. 23.
    Kutner, F. R., and Cohen, J.: Effect of endotoxin on isolated cat paillary muscle. J. Surg. Res., 6:83, 1966.CrossRefGoogle Scholar
  24. 24.
    Kux, M., Coalson, J. J., Jacqueline, J., Massion, W. H., and Guenter, C. A.: Pulmonary effects of E. coli endotoxin role of leukocytes and platelets. Ann. Surg., 175:26, 1972.CrossRefGoogle Scholar
  25. 27.
    Lucas, C. E., Rector, F. E., Werner, M., and Rosenberg, I. K.: Altered renal homeostasis with acute sepsis. Arch. Surg., 106:444, 1973.CrossRefGoogle Scholar
  26. 28.
    McCabe, W. R., Kreger, B. E., and Johns, M.: Type-specific and cross reactive antibodies in gram-negative bacteria. N. Eng. J. Med., 287:261, 1972.CrossRefGoogle Scholar
  27. 29.
    McCoon, R., and Del Guercio, L. R. M.: Respiratory function of blood in the acutely ill patient and the effect of steroids. Ann. Surg., 174:436, 1971.CrossRefGoogle Scholar
  28. 30.
    McKay, D. G., Margaretten, W., and Csavossy, I.: An electron microscope study of endotoxin shock in Rhesus Monkeys. Surg. Gynec. Obstet., 125:825, 1967.Google Scholar
  29. 31.
    Nowotny, A.: Molecular aspects of endotoxin reactions. Bacteriological Reviews, 33:72, 1969.Google Scholar
  30. 32.
    Priano, L. O., Wilson, R. D., and Traber, D. L.: The direct effects of endotoxin on the heart. Proc. Soc. Exp. Biol. Med., 135:495, 1970.Google Scholar
  31. 33.
    Ratnoff, O. D.: The interrelationship of clotting and immunologic mechanism. Hosp. Prac., 6:119, 1971.Google Scholar
  32. 34.
    Robb, H. J., Marqulis, R. R., and Jabs, C. M.: Role of pulmonary microembolism in the hemodynamics of endotoxin shock. Surg. Gynec. Obstet., 135:777, 1972.Google Scholar
  33. 35.
    Rubenstein, H. S., Fine, J., and Coons, A. H.: Localization of endotoxin in the walls of the peripheral vascular system during lethal endotoxemia. Proc. Soc. Exp. Biol. Med., 111:458, 1962.Google Scholar
  34. 36.
    Scheetz, W. L.: Discussion of: Respiratory function of blood in the acutely ill patient and the effect of steroids. By: McCoon, R., and Del Guercio. In: Ann. Surg., 174:449, 1972.Google Scholar
  35. 37.
    Siegel, J. H., and Sonnenblick, E. H.: Isometric time-tension relationships as an index of myocardial contractility. Circ. Resch., 12:597, 1963.Google Scholar
  36. 38.
    Siegel, J. H. and Fabian, M.: Therapeutic advantages of an inotropic vasodilator in endotoxin shock. JAMA, 200:696, 1967.CrossRefGoogle Scholar
  37. 39.
    Skarnes, R. C.: The inactivation of endotoxin after interaction with certain proteins of normal serum. Ann. N. Y. Acad. Science, 133:644, 1966.CrossRefGoogle Scholar
  38. 40.
    Solis, R. T., and Downing, S. E.: Effects of E. coli endotoxemia on ventricular performance. Amer. J. Physiol., 211:307, 1966.Google Scholar
  39. 41.
    Stein, M., and Thomas, D. P.: Role of platelets in the acute pulmonary responses to endotoxin. J. Appl. Physiol., 23:47, 1967.Google Scholar
  40. 42.
    Strauch, M., McLaughlon, S. S., Mansherger, A., Young, J., Mendonca, P., Gray, K., and Cowly, R. A.: Effects of septic shock on renal function in humans. Ann. Surg., 165:539, 1967.Google Scholar
  41. 43.
    White, R. R., Mela, L., Miller, L. D., and Berwich, L.: Effect of E. coli endotoxin on mitochondrial form and function: Inability to complete succinate-induced condensed-to-orthodox conformational changes. Ann. Surg., 174:983, 1971.CrossRefGoogle Scholar
  42. 44.
    Weiner, E., Beck, A., and Shilo, M.: Effect of bacterial lipopoly saccharides on mouse peritoneal leukocytes. Lab. Invest., 14:475, 1965.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Hugh C. Gilbert
    • 1
  • Gerald S. Moss
    • 1
  1. 1.Abraham Lincoln School of MedicineUSA

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