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A New Measure of Genetic Distance

  • Masatoshi Nei

Abstract

In recent years, several authors have proposed different measures of genetic distance between populations (CAVALLI-SFORZA and EDWARDS 1967, MLAKRISHNAN and SANGHVI 1969, HEDRICK 1971, and others). In many of them, however, it is not clear what biological unit they are going to measure. From the standpoint of genetics, the most appropriate measure of genetic distance would be the number of nucleotide or codon differences per unit length of DNA.

Keywords

Genetic Distance House Mouse Gene Difference Gene Substitution Minimum Estimate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. BALAKRISHNAN, V. and L. D. SANGHVI. 1968. Distance between populations on the basis of attribute data. Biometrics 24:859–865.CrossRefGoogle Scholar
  2. CAVALLI-SFORZA, L. L. and A. W. F. EDWARDS. 1967. Phylogenetic analysis: models and estimation procedures. Amer. J. Human Genet. 19:233–257.Google Scholar
  3. CROW, J. F. 1969. Molecular genetics and population genetics. Proc. XII Intern. Congr. Genet., Vol. 3, pp. 105–113.Google Scholar
  4. DAYHOFF, M. O. 1969. Atlas of Protein Sequence and Structure, 1969. National Biomedical Research Foundation, WashingtonGoogle Scholar
  5. HARRIS, H. 1969. Enzyme and protein polymorphism in human populations. British Med. Bull. 25:5–13.Google Scholar
  6. HEDRICK, P. W. 1971. A new approach to measuring genetic similarity. Evolution 25:276–280.CrossRefGoogle Scholar
  7. KIMURA, M. 1968. Evolutionary rate at the molecular level. Nature 217:624–626.PubMedCrossRefGoogle Scholar
  8. KIMURA, M. 1969. The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics 61:893–903.PubMedGoogle Scholar
  9. KIMURA, M. and J. F. CROW. 1964. The number of alleles that can be maintained in a finite population. Genetics 49: 725–738.PubMedGoogle Scholar
  10. KIMURA, M. and T. MARUYAMA. 1971. Pattern of neutral polymorphism in a geographically structured population. Genet. Res. 18:125–131.PubMedCrossRefGoogle Scholar
  11. KIMURA, M. and T. OHTA. 1971. Protein polymorphism as a phase of molecular evolution. Nature 229:467–469.PubMedCrossRefGoogle Scholar
  12. KMURA, M. and G. WEISS. 1964. The steppingstone model of population structure and the decrease of genetic correlation with distance. Genetics 49:561–567.Google Scholar
  13. KING, J. L. and T. H. JUKES. 1969. Non-Darwinian evolution. Science 164:788–798.PubMedCrossRefGoogle Scholar
  14. LAKOVAARA, S., A. SAURA and C.T. FALLS. 1972. Genetic distance and evolutionary relationships in the Drosophila obscvra group. Evolution 26:177–184.CrossRefGoogle Scholar
  15. MALECOT, G. 1959. Les modèles stochastiques en genetique de population. Publ. Inst. Statist. Univ. Paris 8:173–210.Google Scholar
  16. MALECOT, G. 1967. Identical loci and relationship. Proc. Vth Berkeley Symp. Math. Statist. Frobabil., Vol. 4, pp. 317–332.Google Scholar
  17. MARUYAMA, T. 1970. Effective number of alleles in a subdivided population. Theoret. Popul. Biol. 1:273–306.CrossRefGoogle Scholar
  18. MORTON, N. E. 1969. Human population structure. Ann. Rev. Genev. 3:53–74.CrossRefGoogle Scholar
  19. NEI, M. 1969. Gene duplication and nucleotide substitution in evolution. Nature 221:40–43.PubMedCrossRefGoogle Scholar
  20. NEI, M. 1971a. Identity of genes and genetic distance between populations. Genetics 68:s47.Google Scholar
  21. NEI, M. 1971b. Interspecific gene differences and evolutionary time estimated from electrophoretic data on protein identity. Amer. Nat. 105:385–398.CrossRefGoogle Scholar
  22. NEI, M. 1972. Genetic distance betweea populations. Amer. Nat. 106:283–292.CrossRefGoogle Scholar
  23. NEI, M. and A. K. ROYCHOUDHURY. 1972. Gene differences between Caucasian, Negro, and Japaaese populations. Science 177:434–436.PubMedCrossRefGoogle Scholar
  24. NEI, M. and A. K. ROYCHOUDHURY. 1974. Genie variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. Amer. J. Hum. Genet. 26 (in press).Google Scholar
  25. PRAKASH, S., R. C. LEWONTIN and J. L. HUBBY. 1969. A molecular approach to the study of genie heterozygosity in natural populations. IV. Patterns of genie variation in central, marginal and isolated populations of Dro-soplila pseudoobscura. Genetics 61:841–858.Google Scholar
  26. REED, T. E. 1969. Caucasian genes in American Negroes. Science 165:841–858.CrossRefGoogle Scholar
  27. SELANDER, R. K., W. G. HUNT and S. Y. YANG. 1969. Protein polymorphism and genie heterozygosity in two European subspecies of the house mouse. Evolution 23:279–390.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Masatoshi Nei
    • 1
  1. 1.Division of Biological and Medical SciencesBrown UniversityProvidenceUSA

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