The Analysis of Genetic Variation Using Migration Matrices
One of the main aims of the population geneticist is to try to account for observed variations in gene and genotype frequencies over both time and space. Most populations are distributed irregularly in any given geographic area. Population sizes are often small enough so that, when variation over a relatively small geographic area is considered, simple deterministic models to account for the observed genetic variation are unsatisfactory because they ignore fluctuations due to random genetic drift. Though population sizes may be small, it is, nevertheless, rare for any given population to be sufficiently isolated from all others so that migration can be neglected. Even quite low levels of migration between relatively isolated populations may have very significant effects in counteracting divergence between them due to random fluctuations. Models to account for genetic variation observed in restricted geographic areas must, therefore, take into account population subdivisions of the area being studied and rates of migration between these subdivisions.
KeywordsGene Frequency Migration Pattern Central African Republic Random Genetic Drift Angular Transformation
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- CAVALLI-SFORZA, L. L. 1972. Pygmies, an example of hunters-gatherers, and genetic consequences for man of domestication of plants and animals. IV Int. Congr. Human Gen-etics, Paris, Proceedings, 1971. In press.Google Scholar
- CAVALLI-SFORZA, L. L. and W. BODMER. 1971. The Genetics of Human Populations, W. H. Freeman, San Francisco.Google Scholar
- CAVALLI-SFORZA, L. L. and G. ZEI. 1967. Experiments with an artificial population. Proa. Third Int. Congr. Hum, Genet. The Johns Hopkins Press, Baltimore, pp. 473–478.Google Scholar
- CAVALLI-SFORZA, L. L., L. A. ZONTA, F. NUZZO, L. BERNINI, W. V. W. DEJONG, P. MEERA KHAN, A. K. RAY, L. N. WENT, M. SINISCALCO, L. E. NIJENHUIS, E. VANLOGHEM and G. MODIANO. 1969. Studies on African Pygmies. I. A pilot investigation of Babinga Pygmies in the Central African Republic (with an analysis of Genetic distances). Amer. J. Hum. Genet. 21:252–274.PubMedGoogle Scholar
- MALECOT, G. 1950. Quelques schemas probabilistes sur la variabilite des populations naturelles. Ann. Univ. Lyon Sci., A. 13:37–60.Google Scholar
- WRIGHT, S. 1931. Evolution in Mend el ian populations. Genetics 6:144–161.Google Scholar