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Biogenesis of the Yeast Mitochondrial Membranes

  • Anthony W. Linnane
  • Peter D. Crowfoot

Abstract

The approach of our laboratory to the study of mitochondriogenesis has been broadly based, as it was recognized at an early stage of the investigations that the problem is a very complex one. Our studies have encompassed most aspects of the problem, including the properties of the mitochondrial DNA and the identification of its gene products, the nature and characteristics of the mitochondrial protein-synthesizing system, the membrane lipids and their synthesis, and the organization and interaction of the components of the mitochondrial membranes. The yeast system is ideal for such an approach because of the ease with which mitochondrial composition, structure, and function may be varied through the use of various inhibitors, and through physiological and genetic manipulation of the cells. Thus, the mitochondrial and the cytoplasmic protein-synthesizing systems can be separately inhibited, specifically by the administration of antibiotics, while the composition and function of the mitochondria may be varied by anaerobic-aerobic and catabolite repression-derepression growth transitions. Information on both the site of coding of mitochondrial components and the physiological effects resulting from the absence or alteration of these components, including antibiotic resistance, has been obtained by the use of cytoplasmic petite mutants which are characterized by different changes in the mitochondrial DNA. A number of nuclear mutants are also finding increasing use in the field.

Keywords

Mitochondrial Membrane Unsaturated Fatty Acid Adenine Nucleotide Catabolite Repression Yeast Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bandlow, W. (1972), Biochim. Biophys. Acta 282:105.PubMedCrossRefGoogle Scholar
  2. 2.
    Accoceberry, B. and Stahl, A. (1972), C. R. Acad. Sci. Paris, (Ser. D.) 274:3125.Google Scholar
  3. 3.
    Mahler, H. R. (1973), Critical Reviews in Biochemistry 1:381.PubMedCrossRefGoogle Scholar
  4. 4.
    Guidoni, G. (1972), Ann. Rev. Biochem. 41:731.CrossRefGoogle Scholar
  5. 5.
    Parsons, D., Williams, G. R., Thompson, W., Wilson, D. R., and Chance, B. (1967), in: Mitochondrial Structure and Compartmentation (E. Quagliariello, S. Papa, E. C. Slater, and J. M. Tager, eds.), Adriatica Press, Bari, p. 29.Google Scholar
  6. 6.
    McMurray, W. C. and Dawson, R. M. C. (1969), Biochem. J. 112:91.PubMedGoogle Scholar
  7. 7.
    Lukins, H. B., Jollow, D., Wallace, P. G., and Linnane, A. W. (1968), Aust. J. Exp. Biol. Med. Sci. 46:651.PubMedCrossRefGoogle Scholar
  8. 8.
    Paltauf, F. and Schatz, G. (1969), Biochemistry 8:335.PubMedCrossRefGoogle Scholar
  9. 9.
    Parsons, D. and Yano, Y. (1967), Biochim. Biophys. Acta 135:362.PubMedCrossRefGoogle Scholar
  10. 10.
    Linnane, A. W., Halsam, J. M., Lukins, H. B., and Nagley, P. (1972), Ann. Rev. Microbiol. 26:163.CrossRefGoogle Scholar
  11. 11.
    Henson, C. P., Weber, C. N., and Mahler, H. R. (1968), Biochemistry 7:4431.PubMedCrossRefGoogle Scholar
  12. 12.
    Kellerman, G. M., Griffiths, D. E., Hansby, J. E., Lamb, A. J., and Linnane, A. W. (1971), in: Autonomy and Biogenesis of Mitochondria and Chloroplasts (N. K. Boardman, A. W. Linnane, and R. M. Smillie, eds.), North Holland, Amsterdam, p. 346.Google Scholar
  13. 13.
    Mahler, H. R., Perlman, P. S., and Mehrotra, B. D. (1971), in: Autonomy and Biogenesis of Mitochondria and Chloroplasts (N. K. Boardman, A. W. Linnane, and R. M. Smillie, eds.), North Holland, Amsterdam, p. 492.Google Scholar
  14. 14.
    Linnane, A. W. and Haslam, J. M. (1970), in: Current Topics in Cellular Regulation, Vol. 2, Academic Press, New York, p. 101.Google Scholar
  15. 15.
    Ashwell, M. and Work, T. S. (1970), Ann. Rev. Biochem. 39:251.PubMedCrossRefGoogle Scholar
  16. 16.
    Borst, P. (1972),Ann. Rev. Biochem. 41:333.PubMedCrossRefGoogle Scholar
  17. 17.
    Borst, P. and Grivell, L. A. (1971), FEBS Lett. 13:73.PubMedCrossRefGoogle Scholar
  18. 18.
    Forrester, I. T., Nagley, P., and Linnane, A. W. (1970), FEBS Letters 11:59.PubMedCrossRefGoogle Scholar
  19. 19.
    Reijnders, L., Sloof, P., and Borst, P. (1973), Eur. J. Biochem. 35:266.PubMedCrossRefGoogle Scholar
  20. 20.
    Grivell, L. A., Reijnders, L., and Borst, P. (1971), Eur. J. Biochem. 19:64.PubMedCrossRefGoogle Scholar
  21. 21.
    Morimoto, H., Scragg, A. H., Nekhorocheff, J., Villa, V., and Halvorson, H. O. (1971), in: Autonomy and Biogenesis of Mitochondria and Chloroplasts (N. K. Boardman, A. W. Linnane, and R. M. Smillie, eds.), North Holland, Amsterdam, p. 282.Google Scholar
  22. 22.
    Reijnders, L., Kleisen, C. M., Grivell, L. A., and Borst, P. (1972), Biochim. Biophys. Acta 272:396.PubMedGoogle Scholar
  23. 23.
    Nagley, P., Molloy, P. L., Lukins, H. B., and Linnane, A. W. (1974), Biochem. Biophys. Res. Commun. 57:232.PubMedCrossRefGoogle Scholar
  24. 24.
    Reijnders, L. and Borst, P. (1972), Biochem. Biophys. Res. Commun. 47:126.PubMedCrossRefGoogle Scholar
  25. 25.
    Wu, M., Davidson, N., Attardi, G., and Aloni, Y. (1972),J. Mol. Biol. 71:81.PubMedCrossRefGoogle Scholar
  26. 26.
    Constantino, P. and Attardi, G. (1973), Proc. Natl. Acad. Sci. USA 70:1490.CrossRefGoogle Scholar
  27. 27.
    Davey, P. J., Yu, R., and Linnane, A. W. (1969), Biochem. Biophys. Res. Commun. 36:30.PubMedCrossRefGoogle Scholar
  28. 28.
    Groot, G. S. P. (1974), in: The Biogenesis of Mitochondria (A. M. Kroon and C. Saccone, eds.), Academic Press, New York, p. 443.Google Scholar
  29. 29.
    Bunn, C. L., Mitchell, C. H., Lukins, H. B., and Linnane, A. W. (1970), Proc. Nati. Acad. Sci. USA 67:1233.CrossRefGoogle Scholar
  30. 30.
    Grivell, L. A., Reijnders, L., and Borst, P. (1971), Biochim. Biophys. Acta 247:91.PubMedGoogle Scholar
  31. 31.
    Linnane, A. W., Ward, K. A., Forrester, I. T., Haslam, J. M., and Plummer, D. T. (1973), in: Yeast, Mould and Plant Protoplasts (J. R. Villanueva, I. Garcia-Acha, S. Gascon, and F. Uruburu, eds.), Academic Press, London, p. 345.Google Scholar
  32. 32.
    Marzuki, S., Cobon, G., Crowfoot, P., and Linnane, A. W. (1975), Arch. Biochem. Biophys. (submitted for publication).Google Scholar
  33. 33.
    Swanson, R. F. (1971), Nature (Lond.) 231:31.CrossRefGoogle Scholar
  34. 34.
    Grivell, L. A. and Metz, W. (1973), Biochem. Biophys. Res. Commun. 55:125.PubMedCrossRefGoogle Scholar
  35. 35.
    Kellems, R. E., Allison, V. E., and Butow, R. A. (1974),J. Biol. Chem. 249:3297.PubMedGoogle Scholar
  36. 36.
    Kellems, R. E. and Butow, R. A. (1974),J. Biol. Chem. 249:3304.PubMedGoogle Scholar
  37. 37.
    Nagley, P., Molloy, P. L., Lukins, H. B., and Linnane, A. W. (1975), in: The Eukaryote Chromosome (W. J. Peacock and R. D. Brock, eds.), A.N.U. Press, Canberra (in press).Google Scholar
  38. 38.
    Tzagoloff, A., Rubin, M. S., and Sierra, M. F. (1973), Biochim. Biophys. Acta 301:71.PubMedGoogle Scholar
  39. 39.
    Tzagoloff, A. and Meagher, P. (1971),J. Biol. Chem. 246:7328.PubMedGoogle Scholar
  40. 40.
    Senior, A. E. (1973), Biochim. Biophys. Acta 301:249.PubMedGoogle Scholar
  41. 41.
    Tzagoloff, A. (1970),J. Biol. Chem. 245:1545.PubMedGoogle Scholar
  42. 42.
    Schatz, G. (1968),J. Biol. Chem. 243:2192.PubMedGoogle Scholar
  43. 43.
    Kovac, L. and Weissova, K. (1968), Biochim. Biophys. Acta 153:55.PubMedCrossRefGoogle Scholar
  44. 44.
    Tzagoloff, A. (1969),J. Biol. Chem. 244:5027.PubMedGoogle Scholar
  45. 45.
    Tzagoloff, A. (1971),J. Biol. Chem. 246:3050.PubMedGoogle Scholar
  46. 46.
    Tzagoloff, A., Akai, A., and Sierra, M. F. (1972),J. Biol. Chem. 247:6511.PubMedGoogle Scholar
  47. 47.
    Shannon, C., Enns, R., Wheelis, L., Burchiel, K., and Criddle, R. S. (1973),J. Biol. Chem. 248:3004.PubMedGoogle Scholar
  48. 48.
    Sierra, M. F. and Tzagoloff, A. (1973), Proc. Natl. Acad. Sci. USA 70:3155.PubMedCrossRefGoogle Scholar
  49. 49.
    Schatz, G., Groot, G. S. P., Mason, T., Rouslin, W., Wharton, D. C., and Saltzgaber, J. (1972), Fed. Proc. Amer. Soc. Exp. Biol. 31:21.Google Scholar
  50. 50.
    Rubin, M. S. and Tzagoloff, A. (1973),J. Biol. Chem. 248:4269.PubMedGoogle Scholar
  51. 51.
    Chen, W. L. and Charalampous, F. C. (1969),J. Biol. Chem. 244:2767.PubMedGoogle Scholar
  52. 52.
    Kraml, J. and Mahler, H. R. (1967), Immunochemistry 4:213.PubMedCrossRefGoogle Scholar
  53. 53.
    Mason, T. L. and Schatz, G. (1973),J. Biol. Chem. 248:1355.PubMedGoogle Scholar
  54. 54.
    Weiss, J. and Ziganke, B. (1974), in: The Biogenesis of Mitochondria (A. M. Kroon and C. Saccone, eds.), Academic Press, New York, p. 491.Google Scholar
  55. 55.
    Perkins, M., Haslam, J. M., and Linnane, A. W. (1973), Biochem. J. 134:923.PubMedGoogle Scholar
  56. 56.
    Shertzer, H. G. and Racker, E. (1974),J. Biol. Chem. 249:1320.PubMedGoogle Scholar
  57. 57.
    Haslam, J. M., Perkins, M., and Linnane, A. W. (1973), Biochem. J. 134:935.PubMedGoogle Scholar
  58. 58.
    Kolarov, J. and Klingenberg, M. (1974), FEBS Lett. 45:320.PubMedCrossRefGoogle Scholar
  59. 59.
    Perkins, M., Haslam, J. M., Klyce, H. R., and Linnane, A. W. (1973), FEBS Letters 36:137.PubMedCrossRefGoogle Scholar
  60. 60.
    Groot Obbink, D. J., Davey, P., and Linnane, A. W. (1975) (manuscript in preparation).Google Scholar
  61. 61.
    Wirtz, K. W. A. and Zilversmit, D. B. (1968),J. Biol. Chem. 243:3596.PubMedGoogle Scholar
  62. 62.
    Wirtz, K. W. A., Kamp, H. H., and van Deenen, L. L. M. (1972), Biochim. Biophys. Acta 274:606.PubMedCrossRefGoogle Scholar
  63. 63.
    Kiyasu, J. Y., Pieringer, R. A., Paulus, H., and Kennedy, E. P. (1963),J. Biol. Chem. 238:2293.PubMedGoogle Scholar
  64. 64.
    Petzold, G. L. and Agranoff, B. W. (1968),J. Biol. Chem. 242:1187.Google Scholar
  65. 65.
    Stanacev, N. Z., Stuhne-Sekalec, L., Brookes, K. B., and Davidson, J. B. (1969), Biochim. Biophys. Acta 176:650.PubMedGoogle Scholar
  66. 66.
    Hostetler, K. Y. and van den Bosch, H. (1972), Biochim. Biophys. Acta 260:380.PubMedGoogle Scholar
  67. 67.
    Dennis, E. A. and Kennedy, E. P. (1972),J. Lipid Res. 13:263.PubMedGoogle Scholar
  68. 68.
    Shephard, E. H. and Hubscher, G. (1969), Biochem J. 113:429.PubMedGoogle Scholar
  69. 69.
    Zborowski, J. and Wojtczak, L. (1969), Biochim. Biophys. Acta 187:73.PubMedGoogle Scholar
  70. 70.
    Sarzala, M. G., Van Golde, L. M. G., De Kruyff, B., and Van Deenen, L. L. M. (1970) Biochim. Biophys. Acta 202:106.PubMedGoogle Scholar
  71. 71.
    Cobon, G. S., Crowfoot, P. D., and Linnane, A. W. (1974), Biochem. J. 144:265.PubMedGoogle Scholar
  72. 72.
    Crowfoot, P. D., Cobon, G. S., and Linnane, A. W. (1975) (manuscript in preparation).Google Scholar
  73. 73.
    Lynen, F. (1967), in: Organizational Biosynthesis (H. J. Vogel, J. O. Lampen, and V. Bryson, eds.), Academic Press, New York, p. 243.Google Scholar
  74. 74.
    Lynen, F. (1968), in: Aspects of Yeast Metabolism (A. K. Mills and H. Krebs, eds.), Blackwell, Oxford, p. 271.Google Scholar
  75. 75.
    Bloomfield, D. K. and Bloch, K. (1960),J. Biol. Chem. 235:337.PubMedGoogle Scholar
  76. 76.
    Tchen, T. T. and Bloch, K. (1956),J. Am. Chem. Soc. 78:1516.CrossRefGoogle Scholar
  77. 77.
    Tchen, T. T. and Bloch, K. (1957),J. Biol. Chem. 226:931.PubMedGoogle Scholar
  78. 78.
    Proudlock, J. W., Wheeldon, L. W., Jollow, D. J., and Linnane, A. W. (1968), Biochim. Biophys. Acta 152:434.PubMedGoogle Scholar
  79. 79.
    Bücher, N. L. R. and McGarrahan, K. (1956),J. Biol. Chem. 222:1.PubMedGoogle Scholar
  80. 80.
    Amdur, B. H., Rilling, H., and Bloch, K. (1957),J. Am. Chem. Soc. 79:2646.CrossRefGoogle Scholar
  81. 81.
    Shimizu, I., Nagai, J., Hatanaka, H., Saito, E., and Katsuki, H. (1971),J. Biochem. (Tokyo) 70:175.Google Scholar
  82. 82.
    Woods, R. A. (1971),J. Bacteriol. 108:69.PubMedGoogle Scholar
  83. 83.
    Van Wijk, R. and Konijn, J. M. (1971), FEBS Lett. 13:184.PubMedCrossRefGoogle Scholar
  84. 84.
    Fang, M. and Butow, R. A. (1970), Biochem. Biophys. Res. Commun. 41:1579.PubMedCrossRefGoogle Scholar
  85. 85.
    South, D. J. and Mahler, H. R. (1968), Nature (Lond.) 218:1226.CrossRefGoogle Scholar
  86. 86.
    Ainsworth, P. J., Janki, R. M., Tustanoff, E. R., and Ball, A. J. S. (1974) (personal communication).Google Scholar
  87. 87.
    Jollow, D., Kellerman, G. M., and Linnane, A. W. (1968),J. Cell. Biol. 37:221.PubMedCrossRefGoogle Scholar
  88. 88.
    Fukhurara, H. (1969), Eur. J. Biochem. 11:135.CrossRefGoogle Scholar
  89. 89.
    Nagley, P. and Linnane, A. W. (1972), Cell Different. 1:143.CrossRefGoogle Scholar
  90. 90.
    Criddle, R. S. and Schatz, G. (1969), Biochemistry 8:332.CrossRefGoogle Scholar
  91. 91.
    Groot, G. S. P., Kovac, L., and Schatz, G. (1971), Proc. Natl. Acad. Sci. USA 68:308.PubMedCrossRefGoogle Scholar
  92. 92.
    Plattner, H. and Schatz, G. (1969), Biochemistry 8:339.PubMedCrossRefGoogle Scholar
  93. 93.
    Watson, K., Haslam, J. M., and Linnane, A. W. (1970),J. Cell. Biol. 46:88.PubMedCrossRefGoogle Scholar
  94. 94.
    Plattner, H., Salpeter, M. M., Saltzgaber, J., and Schatz, G. (1970), Proc. Natl. Acad. Sci. USA 66:1252.PubMedCrossRefGoogle Scholar
  95. 95.
    Watson, K., Haslam, J. M., Veitch, B., and Linnane, A. W. (1971), in: Autonomy and Biogenesis of Mitochondria and Chloroplasts (N. K. Boardman, A. W. Linnane and R. M. Smillie, eds.), North Holland, Amsterdam, p. 162.Google Scholar
  96. 96.
    Resnick, M. A. and Mortimer, R. K. (1966),J. Bacteriol. 92:597.PubMedGoogle Scholar
  97. 97.
    Proudlock, J. W., Haslam, J. M., and Linnane, A. W. (1971), Bioenergetics 2:327.CrossRefGoogle Scholar
  98. 98.
    Marzuki, S., Cobon, G. S., Haslam, J. M., and Linnane, A. W. (1975), Arch. Biochem. Biophys. (submitted for publication).Google Scholar
  99. 99.
    Haslam, J. M. (1965), Biochim. Biophys. Acta 105:184.PubMedGoogle Scholar
  100. 100.
    Haslam, J. M., Proudlock, J. W., and Linnane, A. W. (1971), Bioenergetics 2:351.CrossRefGoogle Scholar
  101. 101.
    Haslam, J. M., Spithill, T. W., Linnane, A. W., and Chappell, S. B. (1973), Biochem. J. 134:949.PubMedGoogle Scholar
  102. 102.
    Linnane, A. W., Cobon, G. S., and Marzuki, S. (1973), Proceedings of the Third International Specialized Symposium on Yeasts (Helsinki), part 11:349.Google Scholar
  103. 103.
    Marzuki, S., Hall, R. M., and Linnane, A. W. (1974), Biochem. Biophys. Res. Commun. 57:372.PubMedCrossRefGoogle Scholar
  104. 104.
    Subik, J., Kolarov, J., and Kovac, L. (1972), Biochem. Biophys. Res. Commun. 49:192.PubMedCrossRefGoogle Scholar
  105. 105.
    Mattick, J. S., Marzuki, S., Hall, R. M., and Linnane, A. W. (1975) (manuscript in preparation).Google Scholar
  106. 106.
    Mattick, J. S., Hall, R. M., and Linnane, A. W. (1975) (manuscript in preparation)Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Anthony W. Linnane
    • 1
  • Peter D. Crowfoot
    • 1
  1. 1.Department of BiochemistryMonash UniversityVictoriaAustralia

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