Site-Specific Recombination: Genes and Regulation
A dozen years have passed since Allan Campbell (1962) suggested that prophages might associate with the host chromosome through an insertion mechanism accomplished by a reciprocal recombination event. We now know that insertion does occur for most temperate phage and that the insertion reaction is typically catalyzed by a phage-speci-fied pathway of recombination, which is notable for its localization to one or a small number of sites on the phage and host DNA (for reviews see Echols, 1971; Gottesman and Weisberg, 1971).
KeywordsAttachment Site Bacteriophage Lambda Promoter Site Host Chromosome Temperate Phage
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