Site-Specific Recombination: Genes and Regulation

  • Harrison Echols
  • Stephen Chung
  • Linda Green


A dozen years have passed since Allan Campbell (1962) suggested that prophages might associate with the host chromosome through an insertion mechanism accomplished by a reciprocal recombination event. We now know that insertion does occur for most temperate phage and that the insertion reaction is typically catalyzed by a phage-speci-fied pathway of recombination, which is notable for its localization to one or a small number of sites on the phage and host DNA (for reviews see Echols, 1971; Gottesman and Weisberg, 1971).


Attachment Site Bacteriophage Lambda Promoter Site Host Chromosome Temperate Phage 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Harrison Echols
    • 1
  • Stephen Chung
    • 1
  • Linda Green
    • 1
  1. 1.Department of Molecular BiologyUniversity of CaliforniaBerkeleyUSA

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