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Site-Specific Recombination: Genes and Regulation

  • Harrison Echols
  • Stephen Chung
  • Linda Green

Abstract

A dozen years have passed since Allan Campbell (1962) suggested that prophages might associate with the host chromosome through an insertion mechanism accomplished by a reciprocal recombination event. We now know that insertion does occur for most temperate phage and that the insertion reaction is typically catalyzed by a phage-speci-fied pathway of recombination, which is notable for its localization to one or a small number of sites on the phage and host DNA (for reviews see Echols, 1971; Gottesman and Weisberg, 1971).

Keywords

Attachment Site Bacteriophage Lambda Promoter Site Host Chromosome Temperate Phage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Campbell, A. 1962. Episomes. Advan. Genet. 11: 101.Google Scholar
  2. Campbell, A. and J. Zissler. 1966. The steric effect in lysogeni-zation by bacteriophage lambda. III. Superinfection of monolyso-genic derivatives of a strain diploid for the prophage attachment site. Virology 28: 659.PubMedCrossRefGoogle Scholar
  3. Chung, S., L. Green and H. Echols. 1974. Mutants of bacteriophage λ defective in integration but not excision: evidence for an integration-specific protein in site-specific recombination. Submitted for publication.Google Scholar
  4. Echols, H., R. Gingery and L. Moore. 1968. Integrative recombination function of bacteriophage λ: evidence for a site-specific recombination enzyme. J. Mol. Biol. 34: 251.PubMedCrossRefGoogle Scholar
  5. Echols, H. 1970. Integrative and excisive recombination by bacteriophage λ: evidence for an excision-specific recombination protein. J. Mol. Biol. 47: 575.PubMedCrossRefGoogle Scholar
  6. Echols, H. 1971. Lysogeny: Viral repression and site-specific recombination. Ann. Rev. Biochem. 40: 827.PubMedCrossRefGoogle Scholar
  7. Echols, H. 1972. Developmental pathways for the temperate phage: lysis vs. lysogeny. Ann. Rev. Genet. 6: 157.PubMedCrossRefGoogle Scholar
  8. Echols, H. 1974. Constitutive integrative recombination by bacteriophage X. Submitted for publication.Google Scholar
  9. Gingery, R. and H. Echols. 1967. Mutants of bacteriophage λ unable to integrate into the host chromosome. Proc. Nat. Acad. Sci. U.S.A. 58: 1507.CrossRefGoogle Scholar
  10. Gingery, R. and H. Echols. 1968. Integration, excision, and transducing particle genesis by bacteriophage λ. Cold Spring Harbor Symp. Quant. Biol. 33: 721.PubMedCrossRefGoogle Scholar
  11. Gottesman, M. E. and M. B. Yarmolinsky. 1968a. Integration-negative mutants of bacteriophage lambda. J. Mol. Biol. 31: 487.CrossRefGoogle Scholar
  12. Gottesman, M. E. and M. B. Yarmolinsky. 1968b. The integration and excision of the bacteriophage lambda genome. Cold Spring Harbor Symp. Quant. Biol. 33: 735.CrossRefGoogle Scholar
  13. Gottesman, M. E. and R. A. Weisberg. 1971. Prophage insertion and excision. In (D. Hershey, ed.) The Bacteriophage Lambda, pp. 113–138. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  14. Guarneros, G. and H. Echols. 1970. New mutants of bacteriophage λ with a specific defect in excision from the host chromosome. J. Mol. Biol. 47: 565.PubMedCrossRefGoogle Scholar
  15. Herskowitz, I. 1973. Control of gene expression in bacteriophage lambda. Ann. Rev. Genet. 7: 289.PubMedCrossRefGoogle Scholar
  16. Shimada, K. and A. Campbell. 1974. Int-constitutive mutants of bacteriophage lambda. Proc. Nat. Acad. Sci. U.S.A. 71: 237.CrossRefGoogle Scholar
  17. Signer, E. R. 1969. Plasmid formation: a new mode of lysogeny by phage À. Nature 223: 158.PubMedCrossRefGoogle Scholar
  18. Weil, J. and E. R. Signer. 1968. Recombination in bacteriophage A. II. Site-specific recombination promoted by the integration system. J. Mol. Biol. 34: 273.PubMedCrossRefGoogle Scholar
  19. Zissler, J. 1967. Integration-negative (int) mutants of phage λ. Virology 31: 189.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Harrison Echols
    • 1
  • Stephen Chung
    • 1
  • Linda Green
    • 1
  1. 1.Department of Molecular BiologyUniversity of CaliforniaBerkeleyUSA

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