X-Ray and Ultraviolet Light Sensitivities of a Methyl Methanesulfonate-Sensitive Strain of Drosophila melanogaster
Genetic recombination is a multifaceted biological phenomenon with a variety of expressions on a wide range of biological systems. These expressions have in common the interaction of genetic elements to produce reorganized molecules, and this reordering process serves as a fundamental mechanism for introducing biological diversity to these systems. Radding (1973) has classified the types of recom-binational interactions observed into three general categories: general recombination, site-specific recombination, and nonhomologous recombination. Two approaches have been employed for the analysis of these genetic exchange interactions. The more classic methodology utilizes systems which focus on the analysis of recom-binational events by an examination of the exchange products of genetic interactions. More recently systematic investigations of recombinational interactions have aimed at illuminating the underlying genetic and biochemical control mechanisms (e.g. see Clark, 1973). This latter approach drew attention to the demonstrable relationship between recombination deficiency and mutagen sensitivity and suggested that mutagen sensitivity could be an effective indicator not only of deficiencies of DNA repair ability but also of abnormalities of recombination proficiency.
KeywordsMutagen Sensitivity Methyl Methanesulfonate mutS Male Viable Progeny Methyl Methane
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