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Recombination of Mitochondrial Genes in Yeast

  • Bernard Dujon

Abstract

Mitochondrial mutations conferring resistance to specific antibiotics have been isolated in the yeast Saccharomyces cevevisiae. These mutations are located in the mitochondrial DNA (mtDNA) molecule (Nagley and Linnane, 1972; Faye et al., 1973; Deutsch et al., 1974). Mitochondrial recombination in yeast is interesting to consider in a symposium on mechanisms in recombination for several reasons: (1) mitochondrial genetics is a population genetics similar in certain aspects to bacteriophage genetics, (2) the elementary acts of recombination are of the nonreciprocal type, and (3) the occurrence of repetitive sequences in mtDNA of ρ- mutants offers a tool to study recombination in segments of repeated genes. Recently, extensive studies on multifactorial mitochondrial crosses have been published (Kleese et al., 1972; Suda and Uchida, 1972; Avner et al., 1973; Wolf et al., 1973; Howell et al., 1973; Rank, 1973 and Netter et al., 1974), using a standard cross procedure described by Coen et al. (1970), in which a random sample of a population issued from many zygotes after some 20 cell divisions is analyzed.

Keywords

Polar Region Gene Conversion Polar Cross Euglena Gracilis Nonpolar Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Bernard Dujon
    • 1
  1. 1.Centre de Génétique Moléculaire du C.N.R.S.Gif-sur-YvetteFrance

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