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Genetical Interference and Gene Conversion

  • Robert K. Mortimer
  • Seymour Fogel

Abstract

Gene conversion is a phenomenon associated with a high frequency of crossing-over of flanking markers (Mitchell, 1955; Case and Giles, 1964; Fogel and Hurst, 1967). Within a sample of 907 conversion events at four loci in the yeast Saccharomyces cerevisiae, 445 were associated with exchange of bracketing markers (Hurst et al., 1972). The finding that approximately 50% of the conversions were associated with crossing-over applied even when the bracketing alleles were in the same gene as the converted alleles. These results imply a direct relationship between gene conversion and crossing-over. A variety of different models have been proposed to explain recombination as a sequence of molecular events that may result in conversion alone, postmeiotic segregation, or either of these events associated with reciprocal recombination of outside markers (for review see Radding, 1973). A corollary of these models is that a reciprocal recombination event implies the occurrence of a conversion event somewhere between the recombined markers (Fogel and Mortimer, 1969; Paszewski, 1970). However, most and possibly all current models do not address themselves to the question of chiasma interference or the distribution of conversions and/or recombinations in adjacent genetic intervals.

Keywords

Gene Conversion Adjacent Region Flank Marker Conversion Event Adjacent Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Robert K. Mortimer
    • 1
  • Seymour Fogel
    • 1
  1. 1.Division of Medical Physics and Donner Laboratory, and Department of GeneticsUniversity of CaliforniaBerkeleyUSA

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