Transformation in Haemophilus influenzae

  • J. Eugene LeClerc
  • Jane K. Setlow


One of the problems in understanding the mechanism of transformation in Haemophilus influenzae has been that no significant amount of single-strand donor DNA has been found following entrance of the transforming DNA into the competent cell (Notani and Goodgal, 1966). Therefore it has been difficult to imagine how specific pairing and integration could occur. We have attempted to investigate (1) the structure of DNA synthesized in competent cells, (2) the structure of transforming DNA after its entrance into the cell, and (3) the interaction between transforming DNA and recipient cell DNA, in the strains listed in Table 1, in order to assess the effects of various mutations on the recombination process.


Competent Cell Haemophilus Influenzae Strand Region Intermediate Molecular Weight Hemophilus Influenzae 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • J. Eugene LeClerc
    • 1
  • Jane K. Setlow
    • 1
  1. 1.Biology Division, Oak Ridge National LaboratoryThe University of Tennessee-Oak Ridge Graduate School of Biomedical SciencesOak RidgeUSA

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