In Osler’s Day it was Syphilis

  • M. W. Laufer


As is so often the case, the research with which I have been identified had an odd and tortuous beginning. Chance has played an overwhelming role. The medical school to which I went, then known as the Long Island College for Medicine, was a perfect illustration of a trade school rather than a component of a university. Since I had early conceived the thought of becoming a pediatrician, it was my good fortune, in the course of a variety of contrived roles, to meet up with two residents in pediatrics who were university-minded and a cut above their peers. One was Dr. Harold Eisenberg and the other was Dr. Martin Glynn. They kept an eye on my progress and I consulted with them toward the end of what was then the standard two-year internship. Dr. Glynn both guided and paved my way toward a pediatric residency in the prestigious New York Hospital. The time this was to begin was a year past the completion of my internship, and of this year, six months were already planned to be devoted to a term in communicable diseases and tuberculosis at the then-flourishing Kingston Avenue Hospital for Communicable Diseases. This left six unsettled months before the much-desired residency at the New York Hospital was to begin. At this juncture, Dr. Eisenberg offered a suggestion. In his day pediatric residents of the Long Island College Hospital got their communicable disease experience in a hospital with a famous name (the Charles V. Chapin Hospital) in a place that was little known to most of us (Providence, Rhode Island).


Clinical Neurophysiology Specific Learning Disability Cerebral Dysfunction Short Attention Span Minimal Brain Dysfunction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arey, J. B., & Dent, J. Causes of fetal and neonatal death with special reference to pulmonary and inflammatory lesions. Journal of Pediatrics. 1953, 42, 1–25.PubMedCrossRefGoogle Scholar
  2. Arnold, L. E., Kirilcuk, V., Corson, S. A., & Corson, E. O’L. Levoamphetamine and dextroamphetamine: Differential effect on aggression and hyperkinesis in children and dogs. American Journal of Psychiatry, 1973, 130, 165–170.PubMedGoogle Scholar
  3. Arnold, L. E., Wender, P. H., Mccloskey, K., & Snyder, S. H. Levoamphetamine and dextroamphetamine: Comparative efficacy in the hyperkinetic syndrome. Archives of General Psychiatry, 1972, 27, 816–822.PubMedCrossRefGoogle Scholar
  4. Bellak, L. Toward a unified concept of schizophrenia. Journal of Nervous and Mental Diseases, 1955, 121, 60–66.CrossRefGoogle Scholar
  5. Bradley, C. The behavior of children receiving benzedrine. American Journal of Psychiatry, 1937, 94, 577–585.Google Scholar
  6. Bradley, C., & Bowen, M. Amphetamine (Benzedrine) therapy of children’s behavior disorders. American Journal of Orthopsychiatry, 1941, 11, 92–103.CrossRefGoogle Scholar
  7. Bradley, P. B., & Hance, A. J. The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat. Electroencephalography and Clinical Neurophysiology, 1957, 9, 191–215.PubMedCrossRefGoogle Scholar
  8. Corson, S. A., Corson, E. O’L., Kirilcuk, V., Kirilcup, J., Knopp, W., & Arnold, L. F. Differential effects of amphetamines on clinically relevant dog models of hyperkinesis and stereotypy: Relevance to Huntington’s chorea in advances in neurology. 1. In A. Barbeau, T. N. Chase, and G. W. Paulson, (Eds.), New York: Raven Press, 1973.Google Scholar
  9. Corson, S. A., et al. Effects of d-amphetamine on hyperkinetic untrainable dogs. Federation Proceedings, 30, 1971.Google Scholar
  10. Corson, S. A., et al. Black-and-white sound film, 16mm. Experimental control of hyperkinetic and violent behavior in dogs. Narrated by L. E. Arnold. 1972.Google Scholar
  11. De La Cruz, F. F., Fox, B. H., & Roberts, R. H. (Eds.). Minimal brain dysfunction. 205: Annual New York Academy of Sciences, 1973. (396 pages)Google Scholar
  12. Denhoff, E., Laufer, M. W., & Holden, R. H. The syndromes of cerebral dysfunction. Journal of the Oklahoma State Medical Association, 1959, 52, 360–366.PubMedGoogle Scholar
  13. Frosch, J., & Wortis, S. B. A contribution to the nosology of the impulse disorders. American Journal of Psychiatry, 1954, 111, 132–138.PubMedGoogle Scholar
  14. Gardner, R. A. The family book about minimal brain dysfunction. New York: Jason Aronson, 1973.Google Scholar
  15. Gastaut, H., & Hunter, J. An experimental study of the mechanism of photic activation in idiopathic epilepsy. Electroencephalography and Clinical Neurophysiology, 1950, 2, 263–387.PubMedCrossRefGoogle Scholar
  16. Gastaut, H. Combined photic and Metrazol activation of the brain. Electroencephalography and Clinical Neurophysiology, 1950, 2, 249–261.PubMedCrossRefGoogle Scholar
  17. Greenacre, P. Trauma, growth and personality. New York: W. W. Norton, 1952.Google Scholar
  18. Hartocollis, P. The syndrome of minimal brain dysfunction in young adult patients. Bulletin of the Menninger Clinic, 1968, 32, 102–114.PubMedGoogle Scholar
  19. Laufer, M. W. Cerebral dysfunction and behavior disorders in adolescents. American Journal of Orthopsychiatry, 1962, 32, 501–506.PubMedCrossRefGoogle Scholar
  20. Laufer, M. W. Long term management and some follow up findings on the use of drugs with minimal cerebral syndromes. Journal of Learning Disability, 1971, 4, 519–522.CrossRefGoogle Scholar
  21. Laufer, M. W. The dynamic syndrome and minimal brain dysfunction. Pediatric Annals, 1973, 2, 6–86.Google Scholar
  22. Laufer, M. W., & Denhoff, E. Hyperkinetic behavior syndrome in children. Journal of Pediatrics, 1957, 50, 463–474.PubMedCrossRefGoogle Scholar
  23. Laufer, M. W., Denhoff, E., & Rubin, E. A. Photo-Metrazol activation in children. Electroencephalography and Clinical Neurophysiology, 1954, 6, 1–8.PubMedCrossRefGoogle Scholar
  24. Laufer, M. W., Denhoff, E., & Solomons, G. Hyperkinetic impulse disorder in children’s behavior problems. Psychomatic Medicine,1957, 19, 39–49.Google Scholar
  25. Magoun, H. W. An ascending reticular activating system in the brain stem. American Medical Association Archives of Neurology and Psychiatry, 1952, 67, 145–154.PubMedGoogle Scholar
  26. Marrazzi, A. S. Some indications of cerebral humoral mechanisms. Science, 1953, 118, 367–370.PubMedCrossRefGoogle Scholar
  27. Quitkin, F., & Klein, D. F. Two behavioral syndromes in young adults related to possible minimal brain dysfunction. Journal of Psychiatric Research, 1969, 7, 131–142.PubMedCrossRefGoogle Scholar
  28. Rosenfeld, G. B., & Bradley, C. Childhood behavior sequelae of asphyxia in infancy. Pediatrics, 1948, 2, 74–84.PubMedGoogle Scholar
  29. Satterfield, J. H., Lesser, L. I., Saul, R. E., & Cantwell, D. P. Electroencephalographic aspects in the diagnosis and treatment of minimal brain dysfunction. Annals of the New York Academy of Sciences, 1973, 205, 274–282.PubMedCrossRefGoogle Scholar
  30. Schwartz, P. Birthtrauma as a cause of mental deficiency, Exhibition at APA Annual Meeting, Chicago, 1957.Google Scholar
  31. Schwartz, P. Die traumatischen Schädigungen des Zentralnervensystems durch die Geburt: Anatomische Untersuchungen, Ergebn. d. inn. Med. u. Kinderh, 1927, 31, 165.Google Scholar
  32. Shetty, T. Personal communication. Assistant Professor of Medical Science, Brown University Medical Program, 1973.Google Scholar
  33. Walzer, S., & Wolff, P. H., (Eds.). Seminar on minimal cerebral dysfunction in children. Seminars in Psychiatry, 1973, 5.Google Scholar
  34. Watson, C. W., & Denny-Brown, D. Studies of the mechanism of stimulus-sensitive myoclonus in man. Electroencephalography and Clinical Neurophysiology, 1955, 7, 341–356.PubMedCrossRefGoogle Scholar
  35. Wender, P. Minimal brain dysfunction in children. New York: Wesley-Interscience, 1971.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • M. W. Laufer
    • 1
  1. 1.Bradley HospitalRiversideUSA

Personalised recommendations