DNA Polymerases and a Possible Multi-Enzyme Complex for DNA Biosynthesis in Eukaryotes

  • Earl Baril
  • Betty Baril
  • Howard Elford
  • Ronald B. Luftig


During the past decade considerable progress has been made toward understanding the mechanism and control of DNA replication. The greatest advances have come in studies of prokaryotic DNA replication and these results have facilitated studies of eukaryotic DNA replication. The points emerging are that DNA replication in prokaryotes and eukaryotes involves the concerted action of several enzymes, non-enzymic factors and an integrated intracellular arrangement.


Thymidine Kinase Ribonucleotide Reductase Membrane Fragment Thymidylate Synthetase Thymidine Kinase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Baril, E. F., M. D. Jenkins, O. E. Brown and J. Laszlo. 1970. Science. 169: 87.PubMedCrossRefGoogle Scholar
  2. Baril, E. F., O. E. Brown, M. D. Jenkins and J. Laszlo. 1971. Biochemistry. 10: 1981.PubMedCrossRefGoogle Scholar
  3. Baril, E. F. and J. Laszlo. 1971. Advan. Enzyme Regulation. 9: 183.CrossRefGoogle Scholar
  4. Baril, E., B. Baril and H. Elford. 1972. Proc. Amer. Assoc. Cancer Res. 13: 84.Google Scholar
  5. Baril, E. F., M. D. Jenkins, O, E. Brown, J. Laszlo and H. P. Morris. In press. Cancer Res.Google Scholar
  6. Baril, E., B. Baril, R. B. Luftig and H. Elford, Submitted. Proc. Nat. Acad. Sci., U.S.A.Google Scholar
  7. Bucher, N. L, R. and R. A. Malt. 1971. In Regeneration of Liver and Kidney. Little, Brown and Co., Boston. Pp. 55–77.Google Scholar
  8. Chang, L. M. S. and F. J. Bollum. 1971. J. Biol. Chem. 246: 5835.PubMedGoogle Scholar
  9. Chang, L. M. S. and F. J. Bollum. This symposium.Google Scholar
  10. DeLucia, R. and J. Cairns. 1969. Nature. 224: 1164.PubMedCrossRefGoogle Scholar
  11. Elford, H. L., M. Freese, E. Passamani and H. P. Morris. 1970. J. Biol. Chem. 245: 5228.PubMedGoogle Scholar
  12. Hashimoto, T., T. Arima, H. Okuda and S. Fujii. 1972. Cancer Res. 32: 67.PubMedGoogle Scholar
  13. Howk, R. and T. Y. Wang. 1969. Arch. Biochem. Biophys. 133: 238.PubMedCrossRefGoogle Scholar
  14. Jacob, F., S. Brenner and F. Cuzin. 1963. Cold Spr. Harb. Symp. Quant. Biol. 28: 329.CrossRefGoogle Scholar
  15. Karamata, D. and J. D. Gross. 1970. Mol, Gen, Genetics. 108: 277.CrossRefGoogle Scholar
  16. Knippers, R. 1970. Nature. 228: 1050.PubMedCrossRefGoogle Scholar
  17. Romberg, A. 1969. Science, 163: 1410.CrossRefGoogle Scholar
  18. Romberg, T. and M. L. Gefter. 1971. Proc. Nat. Acad. Sci. U.S.A. 68: 761.CrossRefGoogle Scholar
  19. Lomax, M. I. S. and G. R. Greenberg. 1967. J. Biol. Chem. 242: 109.PubMedGoogle Scholar
  20. Lue, P. F. and J. G. Raplan. 1970. Biochim. Biophys. Acta. 220: 365.PubMedGoogle Scholar
  21. Moses, R. E. and C. C. Richardson. 1970. Biochem. Biophys. Res. Commun. 41:1557 and 1565.Google Scholar
  22. Plate, C. A., V. C. Joshi, B. Sedgwick and S. J. Wakil. 1968. J. Biol. Chem. 243: 5349.Google Scholar
  23. Reed, L. and D. J. Cox. 1970. Biochim. Biophys. Acta. 220: 365.Google Scholar
  24. Sedwick, W. D., T. S. Wang and D. Korn. 1972. J. Biol. Chem. 247: 5026.PubMedGoogle Scholar
  25. Smith, R. G. and R. C. Gallo. 1972. Proc. Nat. Acad. Sci., U.S.A. 69: 2879.CrossRefGoogle Scholar
  26. Sneider, T., V. R. Potter and H. P, Morris. 1969, Cancer Res. 29: 40.PubMedGoogle Scholar
  27. Weissbach, A., A. Schlabach, B. Fridlender and A. Bolden. 1971. Nature New Biol. 231: 167.PubMedGoogle Scholar
  28. Weissman, S. M., R. M. S. Smellie and J. Paul. 1960. Biochim. Biophys. Acta. 45:101,PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Earl Baril
    • 1
  • Betty Baril
    • 1
  • Howard Elford
    • 2
  • Ronald B. Luftig
    • 2
  1. 1.Worcester Foundation for Experimental BiologyShrewsburyUSA
  2. 2.Duke University Medical CenterDurhamUSA

Personalised recommendations