Initiation of DNA Synthesis

  • Arthur Kornberg


All the polymerases studied have two basic features: (i) a phosphodiester bridge is formed between the 3’-phosphate group of a deoxyribonucleotide and the 5’-hydroxy1 group at the growing end of a DNA chain called primer DNA; the chain growth is 5’→ 3’; and (ii) each deoxynucleotide added to the chain is selected by base-pair matching to a DNA chain called template DNA.


Soluble Extract Replicative Form Chromosome Replication Phospho Cellulose Ribonucleoside Triphosphate 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Arthur Kornberg
    • 1
  1. 1.Department of BiochemistryStanford University Medical SchoolStanfordUSA

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