Bidirectional Replication of E. coli DNA: A Physical Demonstration
A number of genetic studies (1–3), some of which have been discussed at this meeting, make it clear that the chromosome of Escherichia coli is replicated bidirectionally. Such studies, however, cannot eliminate the possibility that the single linkage group of E. coli is not in fact composed of two separate structures, each of which is replicated unidirectionally. (One would need to presume, for this to be the case, that these structures associate during Hfr transfer in such a way so as to behave as a single structure.)
KeywordsSeparate Structure Daughter Strand Single Linkage Group Thymine Starvation Drop Fraction
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