Primitive Control of Cellular Metabolism

  • M. A. Mitz


Life, as we know it, is the natural consequence of the environment and time. Biological laws are only special cases of the general laws of chemistry and physics. One of the first to state these ideas was A. I. Oparin, who also taught that we will understand the origin of life if we can follow the path back to the earliest life forms and in the process unravel the physics and chemistry of the primitive Earth (1). These teachings have influenced me to look at cell regulatory mechanisms in such terms and in this way complement the fundamental work on origin and evolution of the cell.


Carbon Dioxide Carbon Diox Carbamic Acid Barium Salt Cyclic Amino Acid 


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  1. 1.
    Oparin, A. I., “The Origin of Life,” original in Russian (1936), English Ed. Macmillan Co., 1938. Reissued Dover Co., New York, 1953.Google Scholar
  2. 2.
    Mitz, M. A., Science 123, 1076 (1956).PubMedCrossRefGoogle Scholar
  3. 3.
    Oparin, A. I., “The Origin of Life on Earth,” p. 379, Academic Press, New York, 1957.Google Scholar
  4. 4.
    Mitz, M. A., and Yanari, S. S., J. Am. Chem. Soc. 78, 2649 (1956).CrossRefGoogle Scholar
  5. 5.
    Volini, M., and Mitz, M. A., J. Am. Chem. Soc. 82, 4572 (1960).CrossRefGoogle Scholar
  6. 6.
    Yanari, S., Volini, M., and Mitz, M. A., Biochim. Biophys. Acta 45, 595 (1960).PubMedCrossRefGoogle Scholar
  7. 7.
    Mitz, M. A., Biochim. Biophys. Acta 25, 426 (1957).PubMedCrossRefGoogle Scholar
  8. 8.
    Carter, M. J., Biol. Revs. 47, 465 (1972).CrossRefGoogle Scholar
  9. 9.
    Mitz, M. A., in: “Chemical Evolution and the Origin of Life” ( Buvet, R., and Ponnamperuma, C., eds.), p. 355, North-Holland, Amsterdam, 1971.Google Scholar
  10. 10.
    Faurhalt, C., J. Chim. Phys. 22, 1 (1925).Google Scholar
  11. 11.
    Stadie, W. C., and O’Brien, H., J. Biol. Chem. 242, 1579 (1937).Google Scholar
  12. 12.
    Mitz, M. A., “Proceedings of the Fourth International Conference on the Origin of Life,” Barcelona, Spain, Abstracts, 1973.Google Scholar
  13. 13.
    Lohrmann, R., and Orgel, L. E., Science 171, 490 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • M. A. Mitz
    • 1
  1. 1.National Aeronautics and Space AdministrationUSA

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