Glucose Isomerase: A Case Study of Enzyme-Catalyzed Process Technology

  • Bruce K. Hamilton
  • Clark K. Colton
  • Charles L. Cooney


Process engineering considerations important in the exploitation of enzyme-catalyzed reactions for large-scale production of desired products are illustrated in the context of a case study of glucose isomerase technology. The state of the art of glucose isomerase processing as revealed by journal and patent literature is reviewed and assessed. Among topics covered are enzyme production, immobilization and stabilization, kinetics, reactor design, and product recovery. Some possible future processing objectives, such as production of pure fructose, are discussed.


Immobilize Enzyme Porous Glass Xylose Isomerase Glucose Isomerase Bacillus Coagulans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Bruce K. Hamilton
    • 1
    • 2
  • Clark K. Colton
    • 1
    • 2
  • Charles L. Cooney
    • 1
    • 2
  1. 1.Department of Nutrition and Food Science and Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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