Uric Acid Metabolism in Malignancy

  • E. Fred Saunders


Complications due to uric acid used to be very common in malignancy. In one series of patients with leukemia, 25% had uric acid levels above 12 mg.% at some time during their disease1. Almost all complications related to uric acid excretion can be prevented. Although hyperuricemia may occur with any malignancy, the difficulties in children arise primarily in association with acute leukemia and lymphosarcoma.


Uric Acid Xanthine Oxidase Uric Acid Level Purine Metabolism Acute Gout 
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    KRAKOFF, I. H. and MEYER, R. L.: Prevention of hyperuricemia in leukemia and lymphoma. JAMA, 193: I, 1965.Google Scholar
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    SINKS, L. E.. NEWTON, A. W.. Jr., NAGI, N. A. and STEVENSON, T. D.: A syndrome associated with extreme hyperuricemia in leukemia. J Pediair. 68: 578, 1966.CrossRefGoogle Scholar
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    BAND, P. R., SILVERBERG, D. S. HENDERSON, J. E., ULAN, R. A., WENSEL, R. H, BANERJEE, T. K. and LITTLE, A. S.: Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol. N Engl J Med. 283: 354, 1970.PubMedCrossRefGoogle Scholar

Copyright information

© Ontario Cancer Treatment and Research Foundation 1973

Authors and Affiliations

  • E. Fred Saunders

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