Methotrexate Toxicity

  • M. H. Freedman


After more than 20 years of clinical use, methotrexate has shown itself to be an effective and versatile chemotherapeutic agent. By its antifolate action, it impairs the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), an action that accounts for its clinical usefulness as well as its toxicity.


Acute Leukemia Folinic Acid Methotrexate Therapy Viral Encephalitis Open Lung Biopsy 
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  1. CLARYSSE, A. M., et al.: Pulmonary disease complicating intermittent therapy with methotrexate. JAMA,209: 1861, 1969.Google Scholar
  2. HERSH, E. M., et al.: Hepatotoxic effects of methotrexate. Cancer,19: 600, 1966.PubMedCrossRefGoogle Scholar
  3. RAGAB, A. H., et al.: Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer,25: 580, 1970.PubMedCrossRefGoogle Scholar
  4. KAY, H. E. M., et al.: Encephalopathy in acute leukemia associated with methotrexate therapy. Arch Dis Child, 47: 344, 1972.PubMedCrossRefGoogle Scholar

Copyright information

© Ontario Cancer Treatment and Research Foundation 1973

Authors and Affiliations

  • M. H. Freedman
    • 1
  1. 1.The Hospital for Sick ChildrenTorontoCanada

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