After more than 20 years of clinical use, methotrexate has shown itself to be an effective and versatile chemotherapeutic agent. By its antifolate action, it impairs the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), an action that accounts for its clinical usefulness as well as its toxicity.
KeywordsAcute Leukemia Folinic Acid Methotrexate Therapy Viral Encephalitis Open Lung Biopsy
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