Controlled Clinical Trials in Leukemia in Children

  • L. F. Sinks


Clinicians have long been plagued by the difficulty of distinguishing between effective and noneffective therapy in rare diseases. In the not too distant past, most reports of effectiveness under these conditions can best be described as anecdotal. To overcome some of these defects, Holland, Frei, Zubrod and other interested physicians combined in 1956 to form the Acute Leukemia Group B. The major objectives of this co-operative chemotherapy group were:
  1. 1.

    To enable physicians to treat and study a greater number of patients with rare diseases in a shorter period through a predetermined method;

  2. 2.

    To enable rapid exploitation of animal model systems in man;

  3. 3.

    To shorten the time needed to test well-established drugs with respect to both dose and interval;

  4. 4.

    To facilitate the rapid exploration of the newer chemotherapeutic agents in the treatment of malignant disease.



Acute Lymphocytic Leukemia Acute Leukemia Inducer Dose Animal Model System Pulse Dose 
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Copyright information

© Ontario Cancer Treatment and Research Foundation 1973

Authors and Affiliations

  • L. F. Sinks
    • 1
  1. 1.Roswell Park Memorial InstituteBuffaloUSA

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