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Controlled Clinical Trials in Leukemia in Children

  • L. F. Sinks

Abstract

Clinicians have long been plagued by the difficulty of distinguishing between effective and noneffective therapy in rare diseases. In the not too distant past, most reports of effectiveness under these conditions can best be described as anecdotal. To overcome some of these defects, Holland, Frei, Zubrod and other interested physicians combined in 1956 to form the Acute Leukemia Group B. The major objectives of this co-operative chemotherapy group were:
  1. 1.

    To enable physicians to treat and study a greater number of patients with rare diseases in a shorter period through a predetermined method;

     
  2. 2.

    To enable rapid exploitation of animal model systems in man;

     
  3. 3.

    To shorten the time needed to test well-established drugs with respect to both dose and interval;

     
  4. 4.

    To facilitate the rapid exploration of the newer chemotherapeutic agents in the treatment of malignant disease.

     

Keywords

Acute Lymphocytic Leukemia Acute Leukemia Inducer Dose Animal Model System Pulse Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. SELAWRY, O. S., et al.: New treatment schedule with improved survival in childhood leukemia. JAMA, 194: 75, 1965.Google Scholar
  2. FARBER, S., et al.: Temporary remission in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin). N Engl J Med, 238: 787, 1948.PubMedCrossRefGoogle Scholar
  3. KARON, M., et al.: The role of vincristine in the treatment of childhood acute leukemia. Clin Pharmacol Ther, 7: 332, 1966.PubMedGoogle Scholar
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    OHNUMA, T., HOLLAND, J. R., FREEMAN, A. I. and SINKS, L. F.: Biochemical and pharmacological studies with asparaginase in man. Cancer Res, 30: 2297, 1970.PubMedGoogle Scholar
  5. 5.
    HALAZUN, J. F., WAGNER, H. R., SINKS, L. F. and Members of ALGB: II. Daunorubicin cardiac toxicity in children with acute lymphocytic leukemia. Presented at the XIV International Congress of Hematology, Sao Paulo, Brazil, July 16–22, 1972.Google Scholar

Copyright information

© Ontario Cancer Treatment and Research Foundation 1973

Authors and Affiliations

  • L. F. Sinks
    • 1
  1. 1.Roswell Park Memorial InstituteBuffaloUSA

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