Animal Scale-Up

  • Robert L. Dedrick


The title of this paper is freely adapted from a problem common to the art and science of chemical engineering: “plant scale-up” or “process scale-up.” A chemical reaction or a set of chemical reactions is discovered which leads to a potentially useful product. The basic chemistry is worked out, often in considerable detail, at the bench in glassware. It is necessary to design a plant which will make the product economically and consistent with other constraints imposed by society.


Human Serum Albumin Blood Flow Rate Lean Tissue Free Concentration Brown Bullhead 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adolph, E. F., 1949, Science 109: 579.PubMedCrossRefGoogle Scholar
  2. Bischoff, K. B., and Brown, R. G., 1966, Chem. Eng. Prog. Symp. Ser. No. 66, 62: 33.Google Scholar
  3. Bischoff, K. B., and Dedrick, R. L., 1968, J. Pharm. Sci. 57: 1346.PubMedCrossRefGoogle Scholar
  4. Bischoff, K. B., Dedrick, R. L., and Zaharko, D. S., 1970, J. Pharm. Sci. 59: 149.PubMedCrossRefGoogle Scholar
  5. Bischoff, K. B., Dedrick, R. L., Zaharko, D. S., and Longstreth, J. A., 1971, J. Pharm. Sci. 60: 1129.CrossRefGoogle Scholar
  6. Bischoff, K. B., Himmelstein, K. J., Dedrick, R. L., and Zaharko, D.S., 1973, Advances in Chemistry Series 118, American Chemical Society, Washington, D. C., p. 47.Google Scholar
  7. Bourke, R. S., Gabelnick, H. L., and Young, O., 1970, Exp. Brain Res. 10: 17.PubMedCrossRefGoogle Scholar
  8. Brodie, B. B., Bernstein, E., Mark, L. C., 1952, J. Pharmacol. Exp. Therap. 105: 421.Google Scholar
  9. Brodie, B. B., Kurz, H., and Schanker, L. S., 1960, J. Pharmacol. Exp. Therap. 130: 20.Google Scholar
  10. Brodie, B. B., Mark, L. C., Papper, E. M., Lief, P. A., Bernstein, E., and Rovenstine, E.A., 1950, J. Pharmacol. Exp. Therap. 98: 85.Google Scholar
  11. Brodie, B. B., and Reid, W. D., 1967, Federation Proc. 26: 1062.Google Scholar
  12. Butler, T. C., 1966, in: Conference on Nonhuman Primate Toxicology, p. 68 (C.O. Miller, ed.), Department of Health, Education, and Welfare, FDA, Washington, D.C.Google Scholar
  13. Camiener, G. W., 1967a, Biochem. Pharmacol. 16: 1681.PubMedCrossRefGoogle Scholar
  14. Camiener, G. W., 1967b, Biochem. Pharmacol. 16: 1691.PubMedCrossRefGoogle Scholar
  15. Camiener, G. W., and Smith, C. G., 1965, Biochem. Pharmacol. 14: 1405.PubMedCrossRefGoogle Scholar
  16. Crank, J., 1965, The Mathematics of Diffusion, Oxford, London.Google Scholar
  17. Dedrick, R. L., Bischoff, K. B., and Zaharko, D. S., 1970, Cancer Chemotherapy Rep. Part I, 54: 95.Google Scholar
  18. Dedrick, R. L., Forrester, D. D., and Ho, D. H. W., 1972, Biochem. Pharmacol. 21: 1.PubMedCrossRefGoogle Scholar
  19. Dedrick, R. L., Vantoch, P., Gombos, E. A., and Moore, R., 1967, Trans. Am. Soc. Artificial Internal Organs 13: 236.Google Scholar
  20. Dedrick, R. L., Zaharko, D. S., and Lutz, R. J., 1973, J. Pharm. Sci. 60: 882.CrossRefGoogle Scholar
  21. Freireich, E. J., Gehan, E. A., Rail, D. P., Schmidt, L. H., and Skipper, H. E., 1966, Cancer Chemotherapy Rep. 50: 219.Google Scholar
  22. Gabelnick, H. L., Dedrick, R. L., and Bourke, R. S., 1970, J. Appl. Physiol. 28: 639.Google Scholar
  23. Gillette, J. R., 1965, in: Drugs and Enzymes, p. 9, Proc. 2nd Int. Pharmacol. Mtg. Google Scholar
  24. Haus, E., Halberg, F., Scheving, L. E., Pauly, J. E., Cardosa, S., Kühl, J. F. W., Sothern, R. B., Shiotsuka, R. N., and Hwang, D. S., 1972, Science 177: 80.PubMedCrossRefGoogle Scholar
  25. Himmelblau, D. M., and Bischoff, K. B., 1968, Process Analysis and Simulation, John Wiley, New York.Google Scholar
  26. Krüger-Thiemer, E., Bunger P., Dettli, L., Spring, P., and Wempe, E., 1965-1966, Chemotherapia. 10: 61, 129, 325.CrossRefGoogle Scholar
  27. Krüger-Thiemer, E., Diller, W., and Bunger, P., 1966, in: Antimicrobial Agents and Chemotherapy 1965 (G.L. Hobby, ed.), American Society of Microbiologists, Ann Arbor, Mich.Google Scholar
  28. Loo, R. V., Brennan, M. J., and Talley, R. W., 1965, Proc. Am. Assoc. Cancer Res. 6: 41.Google Scholar
  29. Mark, L. C., and Brand, L., 1964, Bull. N.Y. Acad. Med. 40: 476.PubMedGoogle Scholar
  30. Mellett, L. B., 1969, Prog. Drug Res. 13: 136.PubMedGoogle Scholar
  31. Mount, D. I., and Boyle, H. W., 1969, Environ. Sci. Tech. 3: 1183.CrossRefGoogle Scholar
  32. Mulligan, L. T., and Mellett, L. B., 1969, J. Chromatog. 43: 376.CrossRefGoogle Scholar
  33. Perl, W., Rackow, H., Salanitre, E., Wolf, G. L., and Epstein, R. M., 1965, J. Appl. Physiol. 20: 621.PubMedGoogle Scholar
  34. Price, H. L., Kovnat, P. J., Safer, J. N., Conner, E. H., and Price, M. L., 1960, Clin. Pharmacol. Therap. 1: 16.Google Scholar
  35. Rackow, H., Salanitre, E., Epstein, R. M., Wolf, G. L., and Perl, W., 1965, J. Appl. Physiol. 20: 611.PubMedGoogle Scholar
  36. Rail, D. P., 1967, Federation Proc. 26: 1020.Google Scholar
  37. Reed, D. J., and Woodbury, D. M., 1962, J. Physiol. 164: 252.PubMedGoogle Scholar
  38. Reinberg, A., and Halberg, F., 1971, Ann. Rev. Pharmacol. 11: 455.PubMedCrossRefGoogle Scholar
  39. Saidman, L. J., and Eger, E. I., 1966, Anesthesiology 27: 118.PubMedCrossRefGoogle Scholar
  40. Schmidt-Nielsen, K., 1970, Federation Proc. 29: 1524.Google Scholar
  41. Tomchick, R., Saslaw, L. D., and Waravdekar, V. S., 1968, J. Biol. Chem. 243: 2534.PubMedGoogle Scholar
  42. Wagner, J. G., 1968, Ann. Rev. Pharmacol. 8: 67.PubMedCrossRefGoogle Scholar
  43. Wagner, J. G., 1971, Biopharmaceutics and Relevant Pharmacokinetics, Drug Intelligence Publications, Hamilton, Illinois.Google Scholar
  44. Wagner, J. G., and Damiano, R. E., 1968, J. Clin. Pharmacol. 8: 102.Google Scholar
  45. Werkheiser, W. C., 1971, Ann. N.Y. Acad. Sci. 186: 343.PubMedCrossRefGoogle Scholar
  46. Zaharko, D. S., and Dedrick, R. L., 1973, Proc. 5th Int. Congr. Pharmacol. S. Karger, Basel, Vol. 3, p. 316.Google Scholar
  47. Zaharko, D. S., Dedrick, R. L., and Oliverio, V. T., 1972, Comp. Biochem. Physiol. 42A: 183.CrossRefGoogle Scholar
  48. Zaharko, D. S., and Oliverio, V. T., 1970, Biochem. Pharmacol. 19: 2923.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Robert L. Dedrick
    • 1
  1. 1.Biomedical Engineering and Instrumentation Branch Division of Research ServicesNational Institutes of HealthBethesdaUSA

Personalised recommendations