For the testing of the safety of drugs, food additives, and other chemicals of technological importance, an animal is needed in which the absorption, distribution, excretion, and the rate and pattern of metabolism of these compounds are similar to those of man. Such an animal probably does not exist. Therefore, the question may be asked what animal or animals are likely to come close to man in these respects? To answer this question, let us look at the animals which are regarded as closest to man on an evolutionary scale and see if we can produce a hypothetical phylogenetic scale which might be used for investigating this problem. The zoologist has produced such a scale in relation to the subhuman primates. Similar scales probably exist for other groups of animals such as rodents and carnivores, some of which are our main experimental animals.
KeywordsRhesus Monkey Glucuronic Acid World Monkey Hippuric Acid Phenylacetic Acid
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