Translation of Pharmacokinetics to Clinical Medicine

  • L. Dettli


More than four hundred years ago the famous natural scientist and physician Theophrastus Paracelsus said: “Alle Dinge sind Gift und nichts ist ohne Gift. Nur die Dosis macht’s, dass ein Ding kein Gift sei.” These words for the first time clearly stated that the biological effect (E) of a substance depends quantitatively on the dose (D) administered, i.e.,
$$E = f(D)$$


Elimination Rate Clinical Medicine Drug Accumulation Bioactive Substance Plasma Water 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1972

Authors and Affiliations

  • L. Dettli
    • 1
  1. 1.Department of Internal MedicineUniversity of Basel, BuergerspitalBaselSwitzerland

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