Pharmacokinetics and Cancer Chemotherapy

  • Kenneth B. Bischoff


When considering a specific application of pharmacokinetics, a major consideration must be some of the other relevant aspects of the area. We will begin with a few general considerations of cancer chemotherapy in order to set the stage for the role of pharmacokinetics. This will consist of a brief description of cell kinetics and some of the biochemical events involved in cancer chemotherapy followed by a discussion of some aspects of local tissue and cell uptake of drugs. Finally, the combination of cell kinetics and pharmacokinetics will specifically focus on some recent efforts to model this behavior and compare the results with experiment. Many of these topics have not been extensively synthesized into a working quantitative description of cancer chemotherapy, especially for clinical applications. It is hoped that the description of, and references to, these areas will provide a basis for future work.


Pharmacokinetic Model Cancer Chemotherapy Cytosine Arabinoside Cell Kinetic Maturation Rate 


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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Kenneth B. Bischoff
    • 1
  1. 1.School of Chemical EngineeringCornell UniversityIthacaUSA

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