Classical Pharmacokinetics to the Frontier

  • Edward R. Garrett

Abstract

The obvious has become apparent within the last decade. It is not only the efficacy of a drug at a site of action that determines the intensity and duration of its pharmacological or chemotherapeutic effect, but the amount of drug that gets there and stays. The net effect of the drug on the body results not only from its action on the receptor site in the biophase but from the action of the body on the drug.

Keywords

Permeability Hydrolysis Toxicity Filtration Lithium 

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References

  1. Berman, M., Shahn, E., and Weiss, M. F., 1962, Biophys. J. 2: 275.PubMedCrossRefGoogle Scholar
  2. Dettli, L., 1971, in: Klinische Pharmakologie und Pharmakotherapie (H. P. Kuemmerle, E. R. Garrett, and K. H. Spitzy, eds.), Urban und Schwarzenberg Verlag, Munich.Google Scholar
  3. Dost, F. H., 1968, Grundlagen der Pharmakokinetik, 2nd ed., Thieme Verlag, Stuttgart.Google Scholar
  4. Garrett, E. R., 1964, Antibiotica et Chemotherapia, Advances, Karger Verlag, Basel, Vol. 12, p. 227.Google Scholar
  5. Garrett, E. R., 1969, Advances in the Biosciences, Pergamon Press, New York, Vol. 5, p. 7.Google Scholar
  6. Garrett, E. R., 1971, in: Klinische Pharmakologie und Pharmakotherapie (H. P. Kuemmerle, E. R. Garrett, and K. H. Spitzy, eds.), Urban and Schwarzenberg Verlag, Munich.Google Scholar
  7. Garrett, E. R., and Alway, C. D., 1964, Proceedings of the 3rd International Congress on Chemotherapy, Stuttgart, 1963, Vol. 2.Google Scholar
  8. Garrett, E. R., and Gravenstein, J. S., 1967, Proceedings of the 5th International Congress on Chemotherapy, Vienna, 1967, Vol. 4, p. 105.Google Scholar
  9. Garrett, E. R., and Lambert, H. J., 1966, J. Pharm. Sci., 55: 626.PubMedCrossRefGoogle Scholar
  10. Garrett, E. R., Ågren, A. J., and Lambert, H. J., 1967, Int. J. Clin. Pharmacol., Therapy, Toxicol. 1: 1.Google Scholar
  11. Garrett, E. R., Thomas, R. C., Wallach, D. P., and Alway, C. D., 1960, J. Pharmacol. Exper. Therap. 130: 106.Google Scholar
  12. Krüger-Thiemer, E., 1964, Proceedings of the 3rd International Congress on Chemotherapy, Stuttgart, 1963, Vol. 2, p. 1686.Google Scholar
  13. Krüger-Thiemer, E., 1966, J. Theoret. Biol. 13: 212.CrossRefGoogle Scholar
  14. Krüger-Thiemer, E., Dettli, L., Spring, P., and Diller, W., 1967, Proceedings of the 3rd International Congress of Cybernetic Medicine, Naples, Italy, 1964, p. 249.Google Scholar
  15. Loo, J. C. K., and Riegelman, S., 1968, J. Pharm. Sci. 57: 918.PubMedCrossRefGoogle Scholar
  16. Meyer, M. C., and Guttman, D. E., 1968, J. Pharm. Sci. 57: 895.PubMedCrossRefGoogle Scholar
  17. Nelson, E., 1959, J. Pharm. Sci. 48: 489.CrossRefGoogle Scholar
  18. Nelson, E., 1960, J. Pharm. Sci. 49: 437.CrossRefGoogle Scholar
  19. Nelson, E., 1961, J. Pharm. Sci. 50: 181.PubMedCrossRefGoogle Scholar
  20. Röpke, H., and Riemann, J., 1969, Analog Computer in Chemie und Biologie, Springer-Verlag, Berlin.Google Scholar
  21. Riegelman, S., Loo, J. C. K., and Rowland, M., 1968, J. Pharm. Sci. 57: 117.PubMedCrossRefGoogle Scholar
  22. Wagner, J., and Nelson, E., 1963, J. Pharm. Sci. 52: 610.PubMedCrossRefGoogle Scholar
  23. Wagner, J., and Nelson, E., 1964, J. Pharm. Sci. 53: 1392.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Edward R. Garrett
    • 1
  1. 1.The Beehive, College of Pharmacy J. Hillis Miller Health CenterUniversity of FloridaGainesvilleUSA

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