A Pharmacokinetic Approach to the Treatment of Depression
Treatment with standard doses of the tricyclic antidepressants nortriptyline (NT) and desmethylimipramine (DMI) results in 10- to 30-fold interindividual differences in their steady-state plasma concentrations (Hammer and Sjöqvist, 1967a; Alexanderson and Sjöqvist, 1971).
KeywordsSingle Oral Dose Plasma Clearance Multiple Oral Dose Endogenous Depression Pharmacokinetic Approach
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- Alexanderson, B., 1972b, On interindividual variability in plasma levels of nortriptyline and desmethylimipramine in man: A pharmacokinetic and genetic study, Linköping University Medical Dissertations No. 6.Google Scholar
- Hammer, W., Ideström, C. M., and Sjöqvist, S., 1967b, “Chemical control of antidepressant drug therapy,” In Proceedings of the First International Symposium on Antidepressant Drugs. Milano, 1966, Ed. by S. Garattini and M. N. G. Dukes, Excerpta Med. Intern. Congr. Ser. No. 122: 301–310.Google Scholar
- Hammer, W., Mårtens, S., and Sjöqvist, F., 1969, A comparative study of the metabolism of desmethylimipramine, nortriptyline and oxyphenylbutazone in man. Clin. Pharmacol. Therap. 10: 44–49.Google Scholar
- Kragh-Sørensen, P., Eggert-Hansen, C., and Åsberg, M., 1973, Plasma levels of nortriptyline in the treatment of endogenous depression. I: 113–115.Google Scholar