Pharmacokinetic Studies with Amphetamines: Relationship to Neuropsychiatric Disorders
In Sweden there has been a long-lasting epidemic of amphetamine abuse. It became evident at the end of the fifties and seems to have culminated around 1969. At that time the approximate number of intravenous abusers of high doses of amphetamine was estimated to be 10,000, the majority of whom lived in, or close to, the capital of Sweden (Inghe, 1969). In this area mainlining amphetamine abusers represented about 0.5% of the total population, corresponding to a similar percentage of heroin addicts in New York City at the same time. Since 1969 we have witnessed a rise in opiate abuse, which has gradually changed the drug scene into a more Americanlike picture. The present report deals with pharmacokinetic and clinical studies of effects of high amphetamine doses in intravenous abusers. All studies were carried out in a specialized four-bed metabolic unit, where appropriate cases were received during the period of investigation.
KeywordsAcidic Urine Alkaline Urine Paranoid Psychosis Amphetamine Abuser Basic Metabolite
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