Application of Pharmacokinetic Principles to the Elucidation of Polygenically Controlled Differences in Drug Response

  • Elliot S. Vesell


The preceding chapter illustrated how pharmacokinetic measurements made in families can be employed to define the Mendelian mode of inheritance of certain primary disorders of drug response. The aberrant drug responses about which Dr. LaDu spoke are transmitted by genes at a single genetic locus; such defects are designated simple single factors. Approximately a dozen examples have been gathered of such simple factors which have as primary effects, adverse reactions to drugs (Kalow, 1962; La Du, 1972; Vesell, 1973) (Table I). Of course, many additional inborn errors of metabolism exhibit abnormal drug response as secondary effects.


Drug Response Twin Study Identical Twin Club Foot Mixed Function Oxidase 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Elliot S. Vesell
    • 1
  1. 1.Department of PharmacologyPennsylvania State University College of Medicine Milton S. Hershey Medical CenterHersheyUSA

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